Radak D, Kolar J, Tanaskovic S, Sagic D, Antonic Z, Mitrasinovic A, Babic S, Nenezic D, Ilijevski N
Vascular Surgery Clinic, Dedinje Cardiovascular Institute, School of Medicine, Belgrade University, Heroja Milana Tepića 1 Street, Belgrade, Serbia.
Phlebology. 2012 Jun;27(4):168-72. doi: 10.1258/phleb.2011.011004. Epub 2011 Sep 8.
Multiple areas of stenosis and different levels of obstruction of internal jugular and azygous veins (a condition known as cronic cerebrospinal venous insufficiency) recently emerged as an additional theory to the well-known autoimmune concept, explaining etiology of multiple sclerosis (MS). The aim of our study was to evaluate internal jugular vein (IJV) morphology and haemodynamic characteristics in patients with MS and compare it with well-matched healthy individuals and to evaluate the prevalence of venous flow abnormalities in both groups.
Sixty-four patients with clinically proven MS and 37 healthy individuals were included in our study. In all patients, IJV morphology and haemodynamic characteristics were evaluated by colour Doppler sonography as well as venous flow disorder. The patients were classified into four groups according to MS clinical form presentation. The prevalence of morphological and haemodynamic abnormalities in the IJV were assessed.
The presence of stenosing lesion, mostly intraluminal defects like abnormal IJV valves, were observed in 28 patients (43%) in the MS group, and in 17 patients (45.9%) in the control group (P = NS). By adding haemodynamic Doppler information in the IJV venous outflow was significantly different in 42% of MS patients showing flow abnormalities (27/64), as compared with 8.1% of the controls (3/37), P < 0.001.
In our group of patients, patients suffering from MS had significantly more IJV morphological changes and haemodynamic abnormalities when compared with healthy individuals not suffering from MS. These findings can be well demonstrated by non-invasive and cost-effective Doppler ultrasound.
颈内静脉和奇静脉的多处狭窄区域以及不同程度的阻塞（一种称为慢性脑脊髓静脉功能不全的病症）最近作为一种广为人知的自身免疫概念之外的理论出现，用以解释多发性硬化症（MS）的病因。我们研究的目的是评估MS患者的颈内静脉（IJV）形态和血流动力学特征，并将其与匹配良好的健康个体进行比较，同时评估两组中静脉血流异常的发生率。
我们的研究纳入了64例临床确诊的MS患者和37名健康个体。对所有患者均通过彩色多普勒超声评估IJV形态和血流动力学特征以及静脉血流紊乱情况。根据MS临床表型将患者分为四组。评估IJV形态和血流动力学异常的发生率。
MS组28例患者（43%）和对照组17例患者（45.9%）观察到存在狭窄病变，主要是管腔内缺陷，如异常的IJV瓣膜（P = 无显著性差异）。通过增加IJV血流动力学多普勒信息，42%的MS患者（27/64）出现血流异常，其静脉流出与对照组的8.1%（3/37）有显著差异，P < 0.001。
在我们的患者组中，与未患MS的健康个体相比，MS患者的IJV形态变化和血流动力学异常明显更多。这些发现可以通过无创且经济高效的多普勒超声很好地证实。
