鱼类摄入与中风风险：剂量反应荟萃分析。
Fish consumption and the risk of stroke: a dose-response meta-analysis.
机构信息
Division of Nutritional Epidemiology, National Institute of Environmental Medicine, Karolinska Institutet, Box 210, SE-17177 Stockholm, Sweden.
出版信息
Stroke. 2011 Dec;42(12):3621-3. doi: 10.1161/STROKEAHA.111.630319. Epub 2011 Sep 8.
BACKGROUND AND PURPOSE
Fish consumption has been postulated to reduce the risk of stroke. We conducted a dose-response meta-analysis to summarize the evidence from prospective studies regarding the association between fish consumption and stroke risk.
METHODS
Pertinent studies were identified by searching Embase and PubMed through May 2011 and by reviewing the references of retrieved articles. We included prospective studies that reported relative risks with 95% CIs of stroke for ≥3 categories of fish consumption. Results were combined using a random-effects model.
RESULTS
Fifteen prospective studies, with 9360 stroke events among 383 838 participants, were included. An increment of 3 servings/week in fish consumption was associated with a 6% reduction in risk of total stroke (relative risk, 0.94; 95% CI, 0.89-0.99) without heterogeneity among studies (P=0.15, I2=25.7%). Among 9 studies with results for stroke subtypes, the relative risks were 0.90 (95% CI, 0.84-0.97) for ischemic stroke and 0.90 (95% CI, 0.76-1.06) for hemorrhagic stroke.
CONCLUSIONS
These findings indicate that fish consumption is weakly inversely associated with the risk of stroke.
背景与目的
人们推测鱼类消费可以降低中风的风险。我们进行了一项剂量-反应荟萃分析，以总结前瞻性研究中关于鱼类消费与中风风险之间关联的证据。
方法
通过搜索 Embase 和 PubMed，截止到 2011 年 5 月，并查阅检索到的文章的参考文献，确定了相关研究。我们纳入了报告中风风险相对风险（RR）和 95%置信区间（CI）≥3 类鱼类消费的前瞻性研究。结果使用随机效应模型进行合并。
结果
纳入了 15 项前瞻性研究，383838 名参与者中有 9360 例中风事件。鱼类消费每周增加 3 份与总中风风险降低 6%相关（RR，0.94；95%CI，0.89-0.99），研究之间无异质性（P=0.15，I2=25.7%）。在 9 项具有中风亚型结果的研究中，RR 分别为缺血性中风 0.90（95%CI，0.84-0.97）和出血性中风 0.90（95%CI，0.76-1.06）。
结论
这些发现表明鱼类消费与中风风险呈弱负相关。
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