神经生长因子：治疗脊髓损伤的潜在治疗工具。
Neurotrophins: potential therapeutic tools for the treatment of spinal cord injury.
机构信息
Neurobiology Section, Biological Sciences Division, University of California-San Diego, La Jolla, CA 92093-0366, USA.
出版信息
Neurotherapeutics. 2011 Oct;8(4):694-703. doi: 10.1007/s13311-011-0074-9.
Abstract
Spinal cord injury permanently disrupts neuroanatomical circuitry and can result in severe functional deficits. These functional deficits, however, are not immutable and spontaneous recovery occurs in some patients. It is highly likely that this recovery is dependent upon spared tissue and the endogenous plasticity of the central nervous system. Neurotrophic factors are mediators of neuronal plasticity throughout development and into adulthood, affecting proliferation of neuronal precursors, neuronal survival, axonal growth, dendritic arborization and synapse formation. Neurotrophic factors are therefore excellent candidates for enhancing axonal plasticity and regeneration after spinal cord injury. Understanding growth factor effects on axonal growth and utilizing them to alter the intrinsic limitations on regenerative growth will provide potent tools for the development of translational therapeutic interventions for spinal cord injury.
摘要
脊髓损伤会永久性地破坏神经解剖回路，并导致严重的功能缺陷。然而，这些功能缺陷并非不可改变，一些患者会出现自发性恢复。这种恢复极有可能依赖于未受损的组织和中枢神经系统的内源性可塑性。神经营养因子是整个发育过程和成年期神经元可塑性的介质，影响神经元前体的增殖、神经元存活、轴突生长、树突分支和突触形成。因此，神经营养因子是增强脊髓损伤后轴突可塑性和再生的理想候选物。了解生长因子对轴突生长的影响，并利用它们改变再生生长的内在限制，将为开发脊髓损伤的转化治疗干预措施提供有力工具。
相似文献
1
Neurotrophins: potential therapeutic tools for the treatment of spinal cord injury.神经生长因子：治疗脊髓损伤的潜在治疗工具。
Neurotherapeutics. 2011 Oct;8(4):694-703. doi: 10.1007/s13311-011-0074-9.
2
Delayed intervention with transplants and neurotrophic factors supports recovery of forelimb function after cervical spinal cord injury in adult rats.成年大鼠颈脊髓损伤后，延迟进行移植和神经营养因子干预有助于前肢功能的恢复。
J Neurotrauma. 2006 May;23(5):617-34. doi: 10.1089/neu.2006.23.617.
3
Targeting Neurotrophins to Specific Populations of Neurons: NGF, BDNF, and NT-3 and Their Relevance for Treatment of Spinal Cord Injury.将神经营养因子靶向特定神经元群体：神经生长因子、脑源性神经营养因子和神经营养因子-3及其与脊髓损伤治疗的相关性。
Int J Mol Sci. 2017 Mar 3;18(3):548. doi: 10.3390/ijms18030548.
4
Neurotrophic factors and gene therapy in spinal cord injury.脊髓损伤中的神经营养因子与基因治疗
Neurorehabil Neural Repair. 2000;14(4):265-75. doi: 10.1177/154596830001400403.
5
Adaptive changes in the injured spinal cord and their role in promoting functional recovery.脊髓损伤后的适应性变化及其在促进功能恢复中的作用。
Neurol Res. 2008 Feb;30(1):17-27. doi: 10.1179/016164107X251781.
6
Spinal cord injury: plasticity, regeneration and the challenge of translational drug development.脊髓损伤：可塑性、再生及转化药物开发面临的挑战
Trends Neurosci. 2009 Jan;32(1):41-7. doi: 10.1016/j.tins.2008.09.008. Epub 2008 Oct 30.
7
Transplants and neurotrophic factors increase regeneration and recovery of function after spinal cord injury.移植和神经营养因子可促进脊髓损伤后的再生和功能恢复。
Prog Brain Res. 2002;137:257-73. doi: 10.1016/s0079-6123(02)37020-1.
8
Spontaneous regeneration of intrinsic spinal cord axons in a novel spinal cord slice culture model.新型脊髓切片培养模型中脊髓固有轴突的自发再生
Eur J Neurosci. 2008 May;27(10):2483-92. doi: 10.1111/j.1460-9568.2008.06227.x. Epub 2008 May 29.
9
Viral vector-mediated gene transfer of neurotrophins to promote regeneration of the injured spinal cord.病毒载体介导的神经营养因子基因转移以促进损伤脊髓的再生
Prog Brain Res. 2004;146:451-76. doi: 10.1016/S0079-6123(03)46029-9.
10
Chemogenetic approaches to unravel circuit wiring and related behavior after spinal cord injury.用于揭示脊髓损伤后神经回路连接及相关行为的化学遗传学方法。
Exp Neurol. 2021 Nov;345:113839. doi: 10.1016/j.expneurol.2021.113839. Epub 2021 Aug 10.
引用本文的文献
1
Enhancing Functional Recovery After Spinal Cord Injury Through Neuroplasticity: A Comprehensive Review.通过神经可塑性促进脊髓损伤后的功能恢复：综述
Int J Mol Sci. 2025 Jul 9;26(14):6596. doi: 10.3390/ijms26146596.
2
Targeting connexin 43 expression via scaffold mediated delivery of antisense oligodeoxynucleotide preserves neurons, enhances axonal extension, reduces astrocyte and microglial activation after spinal cord injury.通过支架介导的反义寡脱氧核苷酸递送靶向连接蛋白43表达可在脊髓损伤后保护神经元、增强轴突延伸、减少星形胶质细胞和小胶质细胞激活。
J Tissue Eng. 2023 Feb 10;14:20417314221145789. doi: 10.1177/20417314221145789. eCollection 2023 Jan-Dec.
3
X-ray Irradiation Improves Neurological Function Recovery of Injured Spinal Cord by Inhibiting Inflammation and Glial Scar Formation.X射线照射通过抑制炎症和胶质瘢痕形成改善脊髓损伤后的神经功能恢复。
J Mol Neurosci. 2022 May;72(5):1008-1017. doi: 10.1007/s12031-022-01975-2. Epub 2022 Feb 15.
4
Neurotrophic factors combined with stem cells in the treatment of sciatic nerve injury in rats: a meta-analysis.神经营养因子联合干细胞治疗大鼠坐骨神经损伤：荟萃分析。
Biosci Rep. 2022 Jan 28;42(1). doi: 10.1042/BSR20211399.
5
Human Embryonic Stem Cell-derived Neural Crest Cells Promote Sprouting and Motor Recovery Following Spinal Cord Injury in Adult Rats.人胚胎干细胞衍生的神经嵴细胞促进成年大鼠脊髓损伤后的发芽和运动功能恢复。
Cell Transplant. 2021 Jan-Dec;30:963689720988245. doi: 10.1177/0963689720988245.
6
Diffusion tensor imaging predicting neurological repair of spinal cord injury with transplanting collagen/chitosan scaffold binding bFGF.弥散张量成像预测结合 bFGF 的胶原/壳聚糖支架移植修复脊髓损伤的神经功能。
J Mater Sci Mater Med. 2019 Nov 4;30(11):123. doi: 10.1007/s10856-019-6322-y.
7
Neurological recovery and antioxidant effects of resveratrol in rats with spinal cord injury: a meta-analysis.白藜芦醇对脊髓损伤大鼠的神经恢复及抗氧化作用：一项荟萃分析。
Neural Regen Res. 2020 Mar;15(3):482-490. doi: 10.4103/1673-5374.266064.
8
Biomimicking Fiber Scaffold as an Effective In Vitro and In Vivo MicroRNA Screening Platform for Directing Tissue Regeneration.仿生纤维支架作为一种用于指导组织再生的有效体外和体内微小RNA筛选平台。
Adv Sci (Weinh). 2019 Feb 27;6(9):1800808. doi: 10.1002/advs.201800808. eCollection 2019 May 3.
9
Scaffold-Mediated Sustained, Non-viral Delivery of miR-219/miR-338 Promotes CNS Remyelination.支架介导的 miR-219/miR-338 的持续非病毒递释促进中枢神经系统髓鞘再生。
Mol Ther. 2019 Feb 6;27(2):411-423. doi: 10.1016/j.ymthe.2018.11.016. Epub 2018 Dec 1.
10
Remodeling of lumbar motor circuitry remote to a thoracic spinal cord injury promotes locomotor recovery.胸段脊髓损伤后腰椎运动回路的重塑促进运动功能恢复。
Elife. 2018 Sep 12;7:e39016. doi: 10.7554/eLife.39016.
本文引用的文献
1
Extensive spontaneous plasticity of corticospinal projections after primate spinal cord injury.灵长类动物脊髓损伤后皮质脊髓投射的广泛自发可塑性。
Nat Neurosci. 2010 Dec;13(12):1505-10. doi: 10.1038/nn.2691. Epub 2010 Nov 14.
2
PTEN deletion enhances the regenerative ability of adult corticospinal neurons.PTEN 缺失增强成年皮质脊髓神经元的再生能力。
Nat Neurosci. 2010 Sep;13(9):1075-81. doi: 10.1038/nn.2603. Epub 2010 Aug 8.
3
Local and remote growth factor effects after primate spinal cord injury.灵长类动物脊髓损伤后的局部和远处生长因子效应。
J Neurosci. 2010 Jul 21;30(29):9728-37. doi: 10.1523/JNEUROSCI.1924-10.2010.
4
Clinical outcomes using modest intravascular hypothermia after acute cervical spinal cord injury.急性颈脊髓损伤后采用适度的血管内低温治疗的临床结果。
Neurosurgery. 2010 Apr;66(4):670-7. doi: 10.1227/01.NEU.0000367557.77973.5F.
5
Combined intrinsic and extrinsic neuronal mechanisms facilitate bridging axonal regeneration one year after spinal cord injury.内在和外在神经元机制相结合有助于脊髓损伤一年后轴突再生的桥接。
Neuron. 2009 Oct 29;64(2):165-72. doi: 10.1016/j.neuron.2009.09.016.
6
Stem cells and spinal cord regeneration.干细胞与脊髓再生。
Curr Opin Biotechnol. 2009 Oct;20(5):552-62. doi: 10.1016/j.copbio.2009.09.008.
7
Sensorimotor cortical activation in patients with cervical spinal cord injury with persisting paralysis.感觉运动皮质在持续性瘫痪的颈髓损伤患者中的激活。
Neurorehabil Neural Repair. 2010 Feb;24(2):136-40. doi: 10.1177/1545968309347680. Epub 2009 Oct 6.
8
Chemotropic guidance facilitates axonal regeneration and synapse formation after spinal cord injury.化学趋向性引导促进脊髓损伤后的轴突再生和突触形成。
Nat Neurosci. 2009 Sep;12(9):1106-13. doi: 10.1038/nn.2365. Epub 2009 Aug 2.
9
Endogenous BDNF regulates induction of intrinsic neuronal growth programs in injured sensory neurons.内源性 BDNF 调节损伤感觉神经元中固有神经元生长程序的诱导。
Exp Neurol. 2010 May;223(1):128-42. doi: 10.1016/j.expneurol.2009.07.022. Epub 2009 Jul 28.
10
Induction of corticospinal regeneration by lentiviral trkB-induced Erk activation.通过慢病毒介导的TrkB诱导的Erk激活促进皮质脊髓束再生
Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):7215-20. doi: 10.1073/pnas.0810624106. Epub 2009 Apr 9.
Zotero 插件