Department of Psychology, Dalhousie University, Halifax, Canada.
Psychopharmacology (Berl). 2012 Mar;220(1):155-61. doi: 10.1007/s00213-011-2465-3. Epub 2011 Sep 9.
A growing body of evidence suggests that gambling frequently co-occurs with smoking, yet little is known about the degree to which nicotine and/or tobacco use influences gambling behavior. Nonetheless, an increasing number of studies suggest that acute administration of nicotine may alter other reinforcing behaviors in both animal and human models, raising the possibility that nicotine may also influence gambling behavior and craving.
The purpose of this study was to examine the acute effects of nicotine on subjective and behavioral gambling responses.
Twenty-eight (15 male) regular gamblers who smoke daily completed two double-blind laboratory sessions where their subjective and behavioral responses to video lottery terminal (VLT) gambling were assessed, following the administration of nicotine inhalers (NI; 4 mg deliverable) or placebo inhalers.
NI significantly decreased tobacco-related cravings (p < 0.05) but did not affect gambling-related cravings, VLT betting patterns, or subjective responses (ps > 0.1).
NI were found to acutely suppress tobacco-related cravings without influencing gambling. These results suggest that use of nicotine replacement therapies may be a safe option for gamblers who are attempting to quit smoking.
越来越多的证据表明，赌博经常与吸烟同时发生，但人们对尼古丁和/或烟草使用在多大程度上影响赌博行为知之甚少。尽管如此，越来越多的研究表明，急性给予尼古丁可能会改变动物和人类模型中的其他强化行为，这增加了尼古丁可能也会影响赌博行为和渴望的可能性。
本研究旨在检查尼古丁对主观和行为性赌博反应的急性影响。
28 名（15 名男性）经常赌博且每天吸烟的参与者在完成了两项双盲实验室研究，在使用尼古丁吸入器（NI；可输送 4 毫克）或安慰剂吸入器后，评估他们对视频彩票终端（VLT）赌博的主观和行为反应。
NI 显著降低了与吸烟有关的渴望（p<0.05），但对与赌博有关的渴望、VLT 投注模式或主观反应没有影响（p>0.1）。
NI 被发现可急性抑制与吸烟有关的渴望，而不影响赌博。这些结果表明，使用尼古丁替代疗法可能是试图戒烟的赌徒的安全选择。
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