Gendreau Linda, Barlow Ashley P S, Mason Stephen C
GlaxoSmithKline Consumer Healthcare Weybridge, Surrey, UK.
J Clin Dent. 2011;22(3):90-5.
Dentin hypersensitivity is a common condition that affects the adult population worldwide. NovaMin is technically described as amorphous sodium calcium phosphosilicate, and has been shown in laboratory studies to rapidly occlude dentin tubules and form a protective hydroxyapatite-like layer on the dentin surface. A number of clinical studies investigating the efficacy of NovaMin for the relief of pain from dentin hypersensitivity have been conducted in the United States, Ireland, China, and India. This article reviews the available literature and finds support based on randomized controlled clinical trials for the use of NovaMin in anhydrous toothpaste formulations in providing relief of pain from dentin hypersensitivity.
牙本质过敏是一种影响全球成年人群的常见病症。诺瓦敏（NovaMin）在技术上被描述为无定形磷酸硅钙钠，实验室研究表明它能迅速封闭牙本质小管，并在牙本质表面形成类似羟基磷灰石的保护层。在美国、爱尔兰、中国和印度，已经开展了多项关于诺瓦敏缓解牙本质过敏疼痛疗效的临床研究。本文回顾了现有文献，并基于随机对照临床试验，发现有证据支持在无水牙膏配方中使用诺瓦敏来缓解牙本质过敏引起的疼痛。
