Hamlin David, Mateo Luis R, Dibart Serge, Delgado Evaristo, Zhang Yun Po, DeVizio William
Contract Dental Evaluations, Langhorne, Pennsylvania, USA.
Am J Dent. 2012 Jun;25(3):146-52.
Dentin hypersensitivity is a significant clinical problem that affects numerous individuals. This sharp pain, arising from exposed dentin in response to external stimuli, can be a particularly uncomfortable and unpleasant sensation for patients, because it interferes with their quality of life. The objective of this 24-week, single-center, parallel group, double-blind, stratified and randomized clinical study was to evaluate the clinical efficacy of a single professional treatment with an in-office desensitizing paste followed by twice daily brushing with a desensitizing toothpaste and toothbrush for 24 weeks.
100 adults with confirmed dentin hypersensitivity were randomly assigned into two groups. One group received a single in-office treatment with a desensitizing paste containing 8% arginine and calcium carbonate (marketed as Colgate Sensitive Pro-Relief Desensitizing Paste and Elmex Sensitive Professional desensitizing paste), after dental scaling, followed by 24 weeks of brushing twice daily with a desensitizing toothpaste containing 8% arginine, calcium carbonate with 1450 ppm fluoride as MFP (marketed as Colgate Sensitive Pro-Relief toothpaste and Elmex Sensitive Professional toothpaste) and using the Colgate Sensitive Pro-Relief toothbrush (Test Group). The other group received a single in-office treatment with Nupro-M pumice prophylaxis paste, after dental scaling, followed by 24 weeks of brushing twice daily with a non-desensitizing toothpaste containing 1450 ppm fluoride as MFP and with the Oral-B Indicator toothbrush (Negative Control Group). Hypersensitivity was reexamined immediately after in-office product application and after 8 and 24 weeks of twice daily brushing.
Immediately after professional product application, and after 8 and 24 weeks, subjects assigned to the Test Group demonstrated statistically significant improvements in dentin hypersensitivity compared to subjects assigned to the Negative Control Group in tactile (49.8%, 57.5% and 32.9%, respectively) and air blast (26.0%, 38.4% and 34.3%, respectively) sensitivity scores. The instant reductions in dentin hypersensitivity provided by the single professional application of a desensitizing paste for in-office use, containing 8% arginine and calcium carbonate were maintained by twice daily brushing with the 8% arginine, calcium carbonate toothpaste with 1450 ppm fluoride as MFP and the Colgate Sensitive Pro-Relief toothbrush for at least 24 weeks.
牙本质过敏是一个影响众多人的重要临床问题。这种由暴露的牙本质对外界刺激产生的剧痛，对患者来说可能是一种特别不舒服和不愉快的感觉，因为它会干扰他们的生活质量。这项为期24周的单中心、平行组、双盲、分层随机临床研究的目的是评估单次专业治疗的临床疗效，该治疗包括在诊所使用脱敏糊剂，随后每天使用脱敏牙膏和牙刷刷牙两次，持续24周。
100名确诊为牙本质过敏的成年人被随机分为两组。一组在洗牙后接受单次诊所治疗，使用含8%精氨酸和碳酸钙的脱敏糊剂（商品名为高露洁敏感专业舒缓脱敏糊剂和艾美适敏感专业脱敏糊剂），随后24周每天使用含8%精氨酸、碳酸钙以及1450 ppm氟化物（以单氟磷酸钠形式存在）的脱敏牙膏（商品名为高露洁敏感专业舒缓牙膏和艾美适敏感专业牙膏）刷牙两次，并使用高露洁敏感专业舒缓牙刷（试验组）。另一组在洗牙后接受单次诊所治疗，使用Nupro-M浮石预防性糊剂，随后24周每天使用含1450 ppm氟化物（以单氟磷酸钠形式存在）的非脱敏牙膏刷牙两次，并使用欧乐-B指示牙刷（阴性对照组）。在诊所应用产品后以及每天刷牙两次8周和24周后重新检查过敏情况。
在专业产品应用后即刻，以及8周和24周后，与阴性对照组相比，试验组受试者在触觉（分别为49.8%、57.5%和32.9%）和空气喷射（分别为26.0%、38.4%和34.3%）敏感性评分方面，牙本质过敏有统计学上的显著改善。含8%精氨酸和碳酸钙的诊所使用的脱敏糊剂单次专业应用所带来的牙本质过敏即时减轻效果，通过每天使用含8%精氨酸、碳酸钙以及1450 ppm氟化物（以单氟磷酸钠形式存在）的牙膏刷牙两次和使用高露洁敏感专业舒缓牙刷得以维持至少24周。
