Ashwini S, Swatika K, Kamala D N
Department of Periodontology, Faculty of Dental Sciences, Ramaiah University of Applied Sciences, Bengaluru, Karnataka, India.
Research Coordinator, Group Pharmaceuticals Limited, Bengaluru, Karnataka, India.
Contemp Clin Dent. 2018 Jul-Sep;9(3):330-336. doi: 10.4103/ccd.ccd_735_17.
A considerable number of agents are effective in the treatment of dentin hypersensitivity (DH). The present 2 months' randomized clinical trial compared the desensitizing efficacy of dentifrice containing 5% fluoro calcium phosphosilicate versus 5% calcium sodium phosphosilicate in participants with sensitive teeth.
A total of 60 participants above 18 years of age with a history of DH who displayed a visual analog scale (VAS) score of ≥ 4 to both subjective and thermal sensitivity in at least two teeth at the qualifying as well as baseline visit were considered eligible. Participants were randomly allocated to one of the following dentifrices: 5% fluoro calcium phosphosilicate; 5% calcium sodium phosphosilicate; and a standard dentifrice containing fluoride. Sensitivity scores (VAS) were measured at baseline, immediately after scaling and root planning, at 15, 30, and at 60 days.
A statistically significant reduction in symptoms for all treatment groups from baseline to 15, 30, and 60 days for both measures of sensitivity was observed. A significant reduction in DH with time for all the variables during the 8 weeks of the active phase of the study independent of treatment groups was noted. However, the fluoro calcium phosphosilicate group showed a higher degree of effectiveness in reducing DH, followed by calcium sodium phosphosilicate then standard fluoride dentifrices.
Under the conditions of a clinical trial, the fluoro calcium phosphosilicate group showed a comparable reduction in the symptoms of DH.
相当多的药物对治疗牙本质过敏症（DH）有效。本为期2个月的随机临床试验比较了含5%氟代磷酸钙硅与含5%磷酸硅钠钙的牙膏对牙齿敏感参与者的脱敏效果。
共有60名18岁以上有牙本质过敏症病史的参与者被认为符合条件，这些参与者在资格评估及基线访视时，至少两颗牙齿的主观和热敏感视觉模拟量表（VAS）评分均≥4。参与者被随机分配到以下牙膏组之一：5%氟代磷酸钙硅；5%磷酸硅钠钙；以及一种含氟的标准牙膏。在基线、洗牙和根面平整后即刻、15天、30天和60天时测量敏感度评分（VAS）。
观察到所有治疗组在从基线到15天、30天和60天的两种敏感度测量指标上症状均有统计学显著降低。在研究的8周活跃期内，所有变量随时间的牙本质过敏症均有显著降低，且与治疗组无关。然而，氟代磷酸钙硅组在降低牙本质过敏症方面显示出更高的有效性，其次是磷酸硅钠钙组，然后是标准含氟牙膏组。
在临床试验条件下，氟代磷酸钙硅组在牙本质过敏症症状减轻方面表现相当。
