Universidade Cruzeiro do Sul, Persons with Disabilities Division, São Paulo, Brazil.
J Oral Pathol Med. 2012 Feb;41(2):153-7. doi: 10.1111/j.1600-0714.2011.01074.x. Epub 2011 Sep 11.
Previous studies reported alterations in salivary parameters in cerebral palsy (CP) individuals; however, none of these considered oral motor performance as possibly responsible for these conditions. The aim of this study was to investigate the influence of oral motor performance on the nutritional status and salivary parameters in individuals with CP.
Forty-three individuals aged 11-19 years-old, with spastic CP were included in this study. Oral motor performance was evaluated using the Oral Motor Assessment Scale, which classified the individuals into two groups: subfunctional or functional. Unstimulated saliva was collected and the flow rate was calculated (ml/min). Salivary osmolality was measured using a freezing point depression osmometer. Blood samples were collected to evaluate complete blood count, total protein, albumin/globulin ratio and transferrin levels.
The subfunctional (n = 21) and the functional group (n = 22) did not differ regarding sex (P = 0.193), however the functional group was older (P = 0.023) and had a higher mean BMI (P < 0.001). The subfunctional CP group presented a reduction in salivary flow rate (36.4%) (P < 0.01) and an increase in salivary osmolality (35.5%) (P < 0.001) compared to the functional group. Slightly lower values for red blood cells (millions/mm(3) ) (P < 0.001), hemoglobin (g/dl) (P < 0.009), hematocrit (%) (P = 0.001), number of platelets (N/mm(3) ), total protein (g/dl) and albumin/globulin ratio (P = 0.003 and P = 0.036, respectively) were determined for the subfunctional group, but within the normal range of normality.
Cerebral palsy individuals appear to present impaired adequate hydration due to compromised oral motor performance.
之前的研究报告称脑瘫（CP）个体的唾液参数发生了改变；然而，这些研究均未考虑口腔运动表现是否可能是导致这些情况的原因。本研究旨在探讨口腔运动表现对 CP 个体的营养状况和唾液参数的影响。
本研究纳入了 43 名 11-19 岁的痉挛型 CP 患者。使用口腔运动评估量表评估口腔运动表现，将患者分为亚功能组或功能组。采集非刺激性唾液并计算其流率（ml/min）。使用冰点渗透压计测量唾液渗透压。采集血样以评估全血细胞计数、总蛋白、白蛋白/球蛋白比值和转铁蛋白水平。
亚功能组（n=21）和功能组（n=22）在性别方面无差异（P=0.193），但功能组年龄更大（P=0.023）且 BMI 均值更高（P<0.001）。与功能组相比，亚功能 CP 组的唾液流率（36.4%）降低（P<0.01），唾液渗透压升高（35.5%）（P<0.001）。亚功能组的红细胞（百万/mm³）（P<0.001）、血红蛋白（g/dl）（P<0.009）、红细胞压积（%）（P=0.001）、血小板数（N/mm³）、总蛋白（g/dl）和白蛋白/球蛋白比值（P=0.003 和 P=0.036）均略低，但仍处于正常值范围。
CP 个体的口腔运动表现受损，可能导致其无法充分水合。
