Universidade Cruzeiro do Sul, São Paulo, Brazil.
J Oral Pathol Med. 2013 Jul;42(6):480-5. doi: 10.1111/jop.12047. Epub 2013 Feb 12.
Salivary immunoglobulin A (SIgA) together with innate defenses such as α-amylase, provides the 'first line of defense' against pathogens present at mucosal surfaces. This study aimed to evaluate salivary α-amylase and immunoglobulin A (IgA) in whole saliva of spastic cerebral palsy (CP) individuals.
Whole saliva was collected from 22 CP and 24 sibling volunteers with no neurological damage control groups (CG) (aged 7-14 years). The salivary flow rate, total protein and SIgA concentrations, and α-amylase activity were determined.
The CP group presented higher salivary flow rate (35%) and lower total protein concentration (18%) compared with the CG (P ≤ 0.05). CPG had higher absolute (68%, μg SIgA/ml) and relative (55%, μg SIgA/mg prot and 108%, μg SIgA/min) concentrations of IgA compared with the CG (P ≤ 0.05). CPG had lower relative α-amylase activity (15% mg malt/mg prot and 33%, mg malt/min) compared with the CG (P ≤ 0.05).
This study concluded that CP individuals presented alterations in the profile of salivary proteins involved in the defense system of the oral cavity.
唾液免疫球蛋白 A（SIgA）与α-淀粉酶等先天防御机制一起，为黏膜表面存在的病原体提供了“第一道防线”。本研究旨在评估痉挛性脑瘫（CP）个体全唾液中的唾液α-淀粉酶和免疫球蛋白 A（IgA）。
从 22 名 CP 和 24 名无神经损伤对照组（CG）（年龄 7-14 岁）志愿者中收集全唾液。测定唾液流率、总蛋白和 SIgA 浓度以及α-淀粉酶活性。
CP 组的唾液流率（35%）高于 CG（P≤0.05），总蛋白浓度（18%）低于 CG。CPG 的绝对 IgA 浓度（68%，μg SIgA/ml）和相对浓度（55%，μg SIgA/mg prot 和 108%，μg SIgA/min）均高于 CG（P≤0.05）。CPG 的相对α-淀粉酶活性（15%mg malt/mg prot 和 33%mg malt/min）低于 CG（P≤0.05）。
本研究表明，CP 个体的口腔防御系统相关的唾液蛋白谱发生了改变。
