Lopes Cristina, Duarte Ana Filipa, Correia Osvaldo, Delgado Luís
Serviço e Laboratório de Imunologia Faculdade de Medicina, Universidade do Porto, Portugal.
Dermatol Online J. 2011 Aug 15;17(8):4.
The prevalence of atopic dermatitis is increasing in western societies and this disease has a significant effect on the quality of life of patients and their families. The pathophysiology is complex, but there are recent insights on innate and adaptive immunity dysfunction in this condition that increases the predisposition to colonization/infection with characteristic types of microorganisms. We provide an up-to-date review of the pathophysiology of atopic dermatitis, highlighting the clinical implications of skin barrier dysfunction and immunological deregulation. We suggest a useful approach for handling exacerbations and infectious events.
特应性皮炎在西方社会的患病率正在上升，这种疾病对患者及其家庭的生活质量有重大影响。其病理生理学很复杂，但最近对这种情况下先天性和适应性免疫功能障碍有了新的认识，这增加了患者定植/感染特定类型微生物的易感性。我们提供了一篇关于特应性皮炎病理生理学的最新综述，重点介绍了皮肤屏障功能障碍和免疫失调的临床意义。我们提出了一种处理病情加重和感染事件的有效方法。
