Clinical Department for Respiratory Diseases, Split University Hospital and School of Medicine, University of Split, Split, Croatia.
Public Health. 2011 Oct;125(10):734-7. doi: 10.1016/j.puhe.2011.07.003. Epub 2011 Sep 8.
Tuberculosis and sarcoidosis are chronic granulomatous diseases. Clinical, pathologic and immunologic aspects are similar although different. The authors were interested to highlight possible epidemiological similarities of these two granulomatous diseases. The objective of this study was to evaluate incidence rate as well as age, sex and geographic distribution of sarcoidosis in South Croatia and to compare it with these epidemiological characteristics of tuberculosis.
Retrospective.
The study was including ten years follow up period (1997-2006), and was performed in Split-Dalmatia County, Croatia. All data were collected retrospectively and analyzed using Statistica 7 programme.
The mean annual incidence of sarcoidosis was 3.3/100,000 inhabitants with a mean of 15,6 cases per year. Woman accounted for 61% of all sarcoidosis cases. The mean sarcoidosis patient age was 44.94 ± 11.85 years. The peak age group was 40-49 years (31%). Significant difference according to incidence rate on the islands comparing to the rates on the coast and the mainland was observed (P = 0.003). The mean sarcoidosis mortality rate was 1.2/100,000. Statistically significant differences between sarcoidosis and tuberculosis were observed according the higher number of tuberculosis patients (P < 0.000), among males (P < 0.000), and females, too (P < 0.000) as well as in mortality rates (P = 0.401). Significantly more patients had tuberculosis on the mainland (P < 0.000) and on the coast (P < 0.000), but not in the islands (P = 0.260).
The results from this study showed dissimilarities in classic epidemiological patterns between sarcoidosis and tuberculosis, incidence rates, as well as sex and geographic distribution. Our findings resulted from this study might be starting point for the future epidemiological, genetic, and immunological studies.
肺结核和结节病都是慢性肉芽肿性疾病。虽然临床、病理和免疫方面有所相似，但也存在不同之处。作者感兴趣的是突出这两种肉芽肿性疾病可能存在的流行病学相似性。本研究的目的是评估克罗地亚南部结节病的发病率以及年龄、性别和地理分布，并将其与肺结核的这些流行病学特征进行比较。
回顾性。
本研究包括十年的随访期（1997-2006 年），在克罗地亚的斯普利特-达尔马提亚县进行。所有数据均采用 Statistica 7 程序进行回顾性收集和分析。
结节病的平均年发病率为 3.3/100000 居民，每年平均有 15.6 例。女性占所有结节病病例的 61%。结节病患者的平均年龄为 44.94±11.85 岁。发病高峰年龄组为 40-49 岁（31%）。在岛屿上的发病率与沿海和大陆上的发病率之间观察到显著差异（P=0.003）。结节病的平均死亡率为 1.2/100000。根据患者数量、男性（P<0.000）、女性（P<0.000）以及死亡率（P=0.401），观察到结节病和肺结核之间存在统计学显著差异。在大陆（P<0.000）和沿海地区（P<0.000），但不在岛屿上（P=0.260），有更多的患者患有肺结核。
本研究结果表明，结节病和肺结核在发病率、性别和地理分布等经典流行病学模式方面存在差异。我们的研究结果可能是未来进行流行病学、遗传学和免疫学研究的起点。
