Poljak Nikola Kolja, Didolić Ivona, Colović Zavisa, Kontić Mirko, Jeroncić Iris, Mulić Rosanda
ORL klinika, Klinicki bolnicki centar Split, Split, Hrvatska.
Acta Med Croatica. 2011;65(3):219-26.
To determine epidemiological characteristics of thyroid carcinoma in Dalmatia, and to compare the incidence rate in Dalmatia with that in Croatia.
Retrospective epidemiological study.
Epidemiological indicators of thyroid carcinoma were compared between Dalmatia and Croatia as a whole, while some epidemiological indicators were compared with the characteristics of persons suffering from thyroid carcinoma in Croatia. The study included 651 persons suffering from and/or operated for thyroid carcinoma in Dalmatia between 1997 and 2006. Data were obtained from case histories, including the results of histopathologic analysis. The area of Dalmatia includes Zadar, Sibenik-Knin, Split-Dalmatia and Dubrovnik-Neretva counties (overall 861,060 inhabitants, surface 11,960 square kilometers).
The incidence of thyroid carcinoma in Dalmatia ranged from 5.2 (1997) to 10.2 per 100,000 inhabitants (2006). The mean age adjusted incidence rate of thyroid cancer in the last 10 years was 8.1 in Croatia and 9.32 per 100,000 inhabitants in Dalmatia. All incidence rates observed (Europe and world-age standardized rates, crude incidence, incidence based on research) showed a rising trend and were significantly higher in Dalmatia than in Croatia. According to sex structure, in both study areas thyroid cancer affected predominantly women, who had four times more chances of falling ill. In Dalmatia, in the overall sample, women accounted for 81.4% of all patients. In Dalmatia, papillary thyroid carcinoma was diagnosed in 80.0% of the overall sample. The median age of newly diagnosed thyroid cancer patients was 50 in Dalmatia. There was no statistically significant sex difference in the prevalence of histologic types of thyroid carcinoma in Dalmatia (P=0.318). In both sexes, papillary carcinoma was the most common type, followed by follicular, medullary and anaplastic thyroid carcinomas.
The incidence rate of thyroid cancer showed a rising trend and was significantly higher in Dalmatia than in Croatia. Epidemiological characteristics of thyroid gland carcinoma in Dalmatia were consistent with the reported characteristics of this carcinoma in iodine-sufficient areas: papillary carcinoma was prevalent and the papillary to follicular carcinoma ratio was 6.4:1.
确定达尔马提亚地区甲状腺癌的流行病学特征，并将达尔马提亚地区的发病率与克罗地亚全国的发病率进行比较。
回顾性流行病学研究。
比较达尔马提亚地区与整个克罗地亚的甲状腺癌流行病学指标，同时将一些流行病学指标与克罗地亚甲状腺癌患者的特征进行比较。该研究纳入了1997年至2006年间在达尔马提亚地区患有和/或接受过甲状腺癌手术的651人。数据来自病历，包括组织病理学分析结果。达尔马提亚地区包括扎达尔、希贝尼克-克宁、斯普利特-达尔马提亚和杜布罗夫尼克-内雷特瓦县（总人口861,060人，面积11,960平方公里）。
达尔马提亚地区甲状腺癌的发病率从每10万居民5.2例（1997年）至10.2例（2006年）不等。过去10年克罗地亚甲状腺癌的年龄调整后平均发病率为每10万居民8.1例，达尔马提亚地区为9.32例。所有观察到的发病率（欧洲和世界年龄标准化发病率、粗发病率、基于研究的发病率）均呈上升趋势，且达尔马提亚地区显著高于克罗地亚。从性别结构来看，在两个研究地区，甲状腺癌主要影响女性，女性患病几率是男性的四倍。在达尔马提亚地区，总体样本中女性占所有患者的81.4%。在达尔马提亚地区，总体样本中有80.0%被诊断为乳头状甲状腺癌。达尔马提亚地区新诊断甲状腺癌患者的中位年龄为50岁。达尔马提亚地区甲状腺癌组织学类型的患病率在性别上无统计学显著差异（P = 0.318）。在男女两性中，乳头状癌都是最常见的类型，其次是滤泡状癌、髓样癌和未分化甲状腺癌。
甲状腺癌发病率呈上升趋势，达尔马提亚地区显著高于克罗地亚。达尔马提亚地区甲状腺癌的流行病学特征与碘充足地区该癌症的报道特征一致：乳头状癌普遍，乳头状癌与滤泡状癌的比例为6.4:1。
