Department of Diabetes and Endocrinology, University Hospital of North Staffordshire NHS Trust, Springfield Unit, North Buildings, Stoke-on-Trent ST4 6QG, United Kingdom.
Diabetes Res Clin Pract. 2011 Dec;94(3):e68-71. doi: 10.1016/j.diabres.2011.08.017. Epub 2011 Sep 8.
Rapid improvement in glycaemic control induced by GLP-1 agonist therapy could be yet another illustration of transient or permanent progression of diabetic retinopathy, similar to documented examples such as pregnancy and continuous subcutaneous insulin infusion. Specific guidelines would be needed to monitor this paradoxical phenomenon during treatment with GLP-1 agonists.
GLP-1 激动剂治疗引起的血糖控制迅速改善,可能是糖尿病视网膜病变的暂时或永久性进展的又一个例子,类似于妊娠和持续皮下胰岛素输注等已记录的例子。在使用 GLP-1 激动剂治疗期间,需要有具体的指南来监测这种矛盾现象。