Jambou R, Abissegue B, Gelas H, Ghipponi P M, Farinotti R, Le Bras J, Hengy C
OCEAC B. P., Yaoundé.
Bull Soc Pathol Exot. 1990;83(1):46-52.
The good results achieved in the treatment of malaria with a 7 and 5 days one of quinine (orally dose 8 mg/kg/8 h), incited the authors to try a 3 days long treatment at the same dose. They experimented this protocol on hospitalised children. All patients were free of parasites at day 7 with an average residual concentration quinine of 2.7 +/- 0.8 mg/l. Among the 7 patients with malaria at day 14, 4 didn't require another treatment and 2 presented new infestation. 50% of plasmodial isolated strains were chloroquine resistant and 40% amodiaquine resistant. The efficiency of this protocol could be in favour of its larger use.
使用7天和5天疗程的奎宁（口服剂量8毫克/千克/8小时）治疗疟疾取得了良好效果，这促使作者尝试以相同剂量进行3天疗程的治疗。他们在住院儿童身上试验了该方案。所有患者在第7天时体内均无寄生虫，奎宁的平均残余浓度为2.7 +/- 0.8毫克/升。在第14天时仍患有疟疾的7名患者中，4名无需再次治疗，2名出现了新的感染。50%的疟原虫分离菌株对氯喹耐药，40%对阿莫地喹耐药。该方案的有效性可能有利于其更广泛的应用。
