Hengy C, Eberlé F, Arrive A, Kouka-Bemba D, Gazin P, Jambou R
Centre Pasteur.
Bull Soc Pathol Exot. 1990;83(1):53-60.
The authors evaluate the comparative efficiency of chloroquine and amodiaquine (35 mg/kg during 3 days) for uncomplicated malaria treatment in an area with high chemoresistance level. 236 patients with malaria were examined and treated. 38% of them previously used antimalarials. The increase dosage in comparison with the WHO recommendations (25 mg/kg), lead to no advantages for chloroquine treatment (50% failure), in contrast with amodiaquine (4% failure). Therefore amodiaquine might be preferred in the health field unit for uncomplicated malaria.
作者评估了氯喹和氨酚喹（35毫克/千克，疗程3天）在一个耐药性水平高的地区治疗非复杂性疟疾的相对疗效。对236例疟疾患者进行了检查和治疗。其中38%的患者此前使用过抗疟药。与世界卫生组织的建议剂量（25毫克/千克）相比增加剂量，氯喹治疗无优势（50%治疗失败），而氨酚喹（4%治疗失败）。因此，在卫生领域单位治疗非复杂性疟疾时，氨酚喹可能更受青睐。
