Institut de Biologie du Développement de Marseille-Luminy, CNRS UMR 6216/Aix-Marseille Universités, 13288 Marseille, France.
Cell Metab. 2011 Sep 7;14(3):403-14. doi: 10.1016/j.cmet.2011.07.012.
There is growing evidence that intestinal bacteria are important beneficial partners of their metazoan hosts. Recent observations suggest a strong link between commensal bacteria, host energy metabolism, and metabolic diseases such as diabetes and obesity. As a consequence, the gut microbiota is now considered a "host" factor that influences energy uptake. However, the impact of intestinal bacteria on other systemic physiological parameters still remains unclear. Here, we demonstrate that Drosophila microbiota promotes larval growth upon nutrient scarcity. We reveal that Lactobacillus plantarum, a commensal bacterium of the Drosophila intestine, is sufficient on its own to recapitulate the natural microbiota growth-promoting effect. L. plantarum exerts its benefit by acting genetically upstream of the TOR-dependent host nutrient sensing system controlling hormonal growth signaling. Our results indicate that the intestinal microbiota should also be envisaged as a factor that influences the systemic growth of its host.
越来越多的证据表明，肠道细菌是其后生动物宿主的重要有益伙伴。最近的观察结果表明，共生细菌与宿主能量代谢以及糖尿病和肥胖等代谢疾病之间存在很强的联系。因此，肠道微生物群现在被认为是影响能量摄取的“宿主”因素。然而，肠道细菌对其他全身生理参数的影响仍不清楚。在这里，我们证明了果蝇的微生物群在营养匮乏时促进幼虫生长。我们发现，植物乳杆菌是果蝇肠道的一种共生菌，它本身就足以重现自然微生物群促进生长的效果。植物乳杆菌通过作用于 TOR 依赖性宿主营养感应系统来发挥作用，该系统控制激素生长信号转导，从而发挥其有益作用。我们的结果表明，肠道微生物群也应该被视为影响其宿主全身生长的因素之一。
