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1
Malaria morbidity and pyrethroid resistance after the introduction of insecticide-treated bednets and artemisinin-based combination therapies: a longitudinal study.在推广经杀虫剂处理的蚊帐和青蒿素为基础的联合疗法后疟疾发病率和拟除虫菊酯类药物抗药性:一项纵向研究。
Lancet Infect Dis. 2011 Dec;11(12):925-32. doi: 10.1016/S1473-3099(11)70194-3. Epub 2011 Aug 17.
2
Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion.青蒿素抗疟原虫活性需要血红蛋白摄取和消化。
Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11405-10. doi: 10.1073/pnas.1104063108. Epub 2011 Jun 27.
3
Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria.合成臭氧化物药物候选物 OZ439 为单剂量治愈无并发症疟疾带来新希望。
Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4400-5. doi: 10.1073/pnas.1015762108. Epub 2011 Feb 7.
4
Pyrethroid resistance in African anopheline mosquitoes: what are the implications for malaria control?非洲按蚊对拟除虫菊酯的抗药性:对疟疾控制有何影响?
Trends Parasitol. 2011 Feb;27(2):91-8. doi: 10.1016/j.pt.2010.08.004. Epub 2010 Sep 16.
5
Changes in the burden of malaria in sub-Saharan Africa.撒哈拉以南非洲疟疾负担的变化。
Lancet Infect Dis. 2010 Aug;10(8):545-55. doi: 10.1016/S1473-3099(10)70096-7. Epub 2010 Jul 14.
6
Artemisinin resistance in Plasmodium falciparum malaria.恶性疟原虫疟疾中的青蒿素耐药性。
N Engl J Med. 2009 Jul 30;361(5):455-67. doi: 10.1056/NEJMoa0808859.
7
Genetic diversity and chloroquine selective sweeps in Plasmodium falciparum.恶性疟原虫的遗传多样性与氯喹选择性清除
Nature. 2002 Jul 18;418(6895):320-3. doi: 10.1038/nature00813.
8
Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance.恶性疟原虫消化液泡跨膜蛋白PfCRT的突变及其在氯喹耐药性中作用的证据。
Mol Cell. 2000 Oct;6(4):861-71. doi: 10.1016/s1097-2765(05)00077-8.
9
Randomised comparative study of mefloquine, qinghaosu, and pyrimethamine-sulfadoxine in patients with falciparum malaria.甲氟喹、青蒿素和乙胺嘧啶-磺胺多辛治疗恶性疟患者的随机对照研究。
Lancet. 1984 Dec 15;2(8416):1360-1. doi: 10.1016/s0140-6736(84)92057-9.
10
Antimalarial activity of mefloquine and qinghaosu.甲氟喹和青蒿素的抗疟活性。
Lancet. 1982 Aug 7;2(8293):285-8. doi: 10.1016/s0140-6736(82)90268-9.

青蒿素:源自中草药园的发现。

Artemisinin: discovery from the Chinese herbal garden.

机构信息

Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA.

出版信息

Cell. 2011 Sep 16;146(6):855-8. doi: 10.1016/j.cell.2011.08.024. Epub 2011 Sep 9.

DOI:10.1016/j.cell.2011.08.024
PMID:21907397
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3414217/
Abstract

This year's Lasker DeBakey Clinical Research Award goes to Youyou Tu for the discovery of artemisinin and its use in the treatment of malaria--a medical advance that has saved millions of lives across the globe, especially in the developing world.

摘要

今年的拉斯克-德贝基临床医学研究奖授予屠呦呦,以表彰她发现青蒿素并将其用于治疗疟疾——这一医疗进步挽救了全球数百万人的生命,特别是在发展中国家。