Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520-8002, USA.
Cell. 2011 Sep 16;146(6):851-4. doi: 10.1016/j.cell.2011.08.041. Epub 2011 Sep 9.
F.-Ulrich Hartl and Arthur Horwich will share this year's Lasker Basic Medical Science Award for the discovery of the cell's protein-folding machinery, exemplified by cage-like structures that convert newly synthesized proteins into their biologically active forms. Their fundamental findings reveal mechanisms that operate in normal physiologic processes and help to explain the problems that arise in diseases of protein folding.
弗利克-乌尔里希·哈特和亚瑟·霍里奇将共同获得今年的拉斯克基础医学研究奖，以表彰他们发现细胞的蛋白质折叠机制，其中包括笼状结构，可将新合成的蛋白质转化为具有生物活性的形式。他们的重要发现揭示了在正常生理过程中起作用的机制，并有助于解释蛋白质折叠疾病中出现的问题。
