Mouse Imaging Centre, Hospital for Sick Children, and Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
Curr Opin Genet Dev. 2011 Oct;21(5):638-46. doi: 10.1016/j.gde.2011.08.009. Epub 2011 Sep 8.
Mammalian development is a sophisticated program coordinated by a complex set of genetic and physiological factors. Alterations in anatomy or morphology provide intrinsic measures of progress in or deviations from this program. Emerging three-dimensional imaging methods now allow for more sophisticated morphological assessment than ever before, enabling comprehensive phenotyping, visualization of anatomical context and patterns, automated and quantitative morphological analysis, as well as improved understanding of the developmental time course. Furthermore, these imaging tools are becoming increasingly available and will consequently play a prominent role in elucidating the factors that direct and influence mammalian development.
哺乳动物的发育是一个由复杂的遗传和生理因素协调的复杂程序。解剖结构或形态的改变为该程序的进展或偏离提供了内在的衡量标准。新兴的三维成像方法现在比以往任何时候都能够进行更复杂的形态评估，实现全面的表型分析、解剖结构和模式的可视化、自动化和定量形态分析，以及更好地理解发育的时间进程。此外，这些成像工具越来越普及，因此将在阐明指导和影响哺乳动物发育的因素方面发挥重要作用。
