Department of Medicine, Rheumatology Unit, Faculty of Medical Science, State University of Campinas, Cidade Universitária, Campinas SP, CEP 13083-970, Brazil.
Cytokine. 2011 Dec;56(3):537-43. doi: 10.1016/j.cyto.2011.08.026. Epub 2011 Sep 9.
The Tumor Necrosis Factor-alpha (TNF-α) is a pleiotropic cytokine that produces different stimuli in various physiological and pathological conditions. TNF-α contributes importantly to the development of T cells, B cells, and dendritic cells. However, TNF-α is also a potent inflammatory mediator and apoptosis inducer. The significance of the TNF-α involvement in the pathogenesis of systemic lupus erythematosus (SLE) remains controversial. From the genetic standpoint, a number of studies suggest that the TNF-α gene polymorphism is involved in the susceptibility of SLE. Moreover, there is a close association between the TNF-α gene expression and clinical manifestations. In addition, the increased serum level of TNF-α is observed in SLE patients and associated with disease activity and certain systemic manifestations. Treatment with anti-TNF agents is, however, controversial in SLE since induction of antinuclear antibodies, anti-dsDNA, anticardiolipin antibodies, and cases of drug-induced lupus have been observed in rheumatoid arthritis patients. In this context, this study reviewed the importance of TNF-α in the pathogenesis of SLE.
肿瘤坏死因子-α（TNF-α）是一种多功能细胞因子，在各种生理和病理条件下产生不同的刺激。TNF-α 对 T 细胞、B 细胞和树突状细胞的发育有重要贡献。然而，TNF-α也是一种有效的炎症介质和凋亡诱导剂。TNF-α 在系统性红斑狼疮（SLE）发病机制中的作用仍存在争议。从遗传角度来看，许多研究表明 TNF-α 基因多态性与 SLE 的易感性有关。此外，TNF-α 基因表达与临床表现之间存在密切关联。此外，SLE 患者血清 TNF-α 水平升高，并与疾病活动度和某些全身表现相关。然而，抗 TNF 药物治疗在 SLE 中存在争议，因为在类风湿关节炎患者中观察到了抗核抗体、抗双链 DNA 抗体、抗心磷脂抗体和药物诱导的狼疮病例。在这种情况下，本研究综述了 TNF-α 在 SLE 发病机制中的重要性。
