Department of Cellular and Molecular Medicine, University of Ottawa, Ontario, Canada.
Behav Brain Res. 2012 Feb 14;227(2):426-32. doi: 10.1016/j.bbr.2011.08.045. Epub 2011 Sep 3.
In response to stroke, the adult brain has the remarkable ability to enhance the proliferation of new cells, which form new neurons in restricted regions. This review focuses on studies that have directly tested the hypothesis that neurogenesis contributes to post-stroke behavioral recovery. The translational potential of this area of research is critically assessed with respect to the selection of appropriate stroke models, subjects, neurogenic regions examined, behavioral tests used, and experimental timecourse. Building upon those studies that suggest an association between endogeneous neurogenesis and improved stroke recovery, we are nonetheless left with the challenge to demonstrate a causal link between neurogenesis and behavioral recovery using new technology.
针对中风，成人大脑具有显著的增强新细胞增殖的能力，这些新细胞会在特定区域形成新的神经元。本综述重点关注了那些直接检验神经发生有助于中风后行为恢复这一假说的研究。从选择合适的中风模型、研究对象、检测的神经发生区域、使用的行为测试以及实验时间进程等方面，对该研究领域的转化潜力进行了严格评估。在那些表明内源性神经发生与改善中风恢复之间存在关联的研究基础上，我们仍然面临着一个挑战，即需要利用新技术来证明神经发生与行为恢复之间的因果关系。
