Bacterial Diseases Branch, Division of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, 3150 Rampart Road, Fort Collins, CO 80521, USA.
Comp Immunol Microbiol Infect Dis. 2011 Dec;34(6):465-73. doi: 10.1016/j.cimid.2011.08.001. Epub 2011 Sep 9.
Groups of Swiss Webster outbred mice were each inoculated with one of four bartonella strains originally isolated from Rattus spp. at doses ranging from 10(1) to 10(7) bacteria per mouse. One strain, Rn1691yn (Bartonella coopersplainensis-like), infected mice and produced bacteremias at levels up to 10(5)bacteria/ml of blood and from 3 to 8 weeks duration. A dose dependent response was also observed with differing proportions of mice bacteremic following inoculation at different doses. In addition weeks-to-months long lags in bacteremia manifestation occurred following lower dose exposures. The possibility of bacterial transmission from bacteremic mice to uninfected cagemates was assessed and no naïve mice became infected from contacts with infected mice. Finally, a subset of bacteremic mice inoculated with high doses of Rn1691yn were examined histopathologically and multifocal, granulomatous lesions were detected in both liver and kidneys. The host specificity and infectivity of the strains is discussed in relation to their potential for zoonotic transmission to incidental hosts.
瑞士韦伯斯特远交系小鼠被分为几组，每组接种一种从 Rattus spp. 中分离得到的巴通体菌株，剂量范围为每只小鼠 10(1)至 10(7)个细菌。一种菌株 Rn1691yn（Bartonella coopersplainensis-like）感染了小鼠，并产生了高达 10(5)细菌/ml 的菌血症，持续时间为 3 至 8 周。在不同剂量接种时，也观察到了剂量依赖性的反应，即在接种后不同比例的小鼠发生菌血症。此外，在较低剂量暴露后，菌血症的表现会出现数周到数月的延迟。从菌血症小鼠向未感染的同笼小鼠传播细菌的可能性进行了评估，没有未感染的小鼠通过与感染小鼠的接触而感染。最后，对高剂量接种 Rn1691yn 的一组菌血症小鼠进行了组织病理学检查，在肝脏和肾脏中均检测到了多灶性、肉芽肿性病变。菌株的宿主特异性和感染性与其向偶然宿主发生人畜共患传播的潜力有关。
