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裴氏瓶霉引起的着色芽生菌病

Chromoblastomycosis Caused by Fonsecaea pedrosoi.

作者信息

Kim Dong Min, Hwang Sung Min, Suh Moo Kyu, Ha Gyoung Yim, Choi Gwang Seong, Shin Jeonghyun, Han Sung Hyub

机构信息

Department of Dermatology, College of Medicine, Dongguk University, Gyeongju, Korea.

出版信息

Ann Dermatol. 2011 Aug;23(3):369-74. doi: 10.5021/ad.2011.23.3.369. Epub 2011 Aug 6.

DOI:10.5021/ad.2011.23.3.369
PMID:21909211
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3162270/
Abstract

We report herein a case of chromoblastomycosis caused by Fonsecaea (F.) pedrosoi in a 39-year-old male, who showed multiple, asymptomatic, scaly erythematous plaques on the left shin for 12 months. Histopathologically, chronic granulomatous inflammation and either sclerotic or muriform cells were observed. The fungal culture produced typical black colonies of F. pedrosoi. The DNA sequence of the internal transcribed spacer (ITS) region of the clinical sample was 100% match to that of F. pedrosoi IFM 47061 (GenBank accession number AB240943). The patient was treated with 200 mg of itraconazole daily, for 3 months. Skin lesions were improved. In Korea, only 9 cases of chromoblastomycosis, including this case, have been reported until now. The etiologic agent was F. pedrosoi in the majority of cases (6/9;67%). The incidence of chromoblastomycosis was slightly higher in female, and the upper limbs were more affected than the lower limbs in patients.

摘要

我们在此报告一例由裴氏瓶霉引起的着色芽生菌病，患者为一名39岁男性，其左小腿出现多个无症状的鳞屑性红斑斑块，持续12个月。组织病理学检查可见慢性肉芽肿性炎症以及硬化细胞或砖壁样细胞。真菌培养产生了裴氏瓶霉典型的黑色菌落。临床样本的内转录间隔区（ITS）区域的DNA序列与裴氏瓶霉IFM 47061（GenBank登录号AB240943）的序列100%匹配。患者接受每日200毫克伊曲康唑治疗，为期3个月。皮肤病变有所改善。在韩国，截至目前，包括该病例在内仅报告了9例着色芽生菌病。在大多数病例（6/9；67%）中，病原体为裴氏瓶霉。着色芽生菌病在女性中的发病率略高，且患者上肢受累比下肢更多。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb72/3162270/aba4b9851489/ad-23-369-g008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb72/3162270/7aa0a6216d83/ad-23-369-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb72/3162270/1ef9ec3aa4da/ad-23-369-g002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb72/3162270/56b0dcc152b5/ad-23-369-g004.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb72/3162270/d783f556eed9/ad-23-369-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb72/3162270/7d15a68719db/ad-23-369-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb72/3162270/aba4b9851489/ad-23-369-g008.jpg

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本文引用的文献

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Chromoblastomycosis: an overview of clinical manifestations, diagnosis and treatment.着色芽生菌病：临床表现、诊断及治疗概述
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Biology and pathogenesis of Fonsecaea pedrosoi, the major etiologic agent of chromoblastomycosis.裴氏着色芽生菌的生物学特性与发病机制，着色芽生菌病的主要病原体。
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A case of chromomycosis caused by Fonsecaea pedrosoi and a review of reported cases of dematiaceous fungal infection in Japan.一株由裴氏瓶霉引起的着色芽生菌病病例及日本报道的暗色真菌感染病例回顾
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A case of chromoblastomycosis with an unusual clinical manifestation caused by Phialophora verrucosa on an unexposed area: treatment with a combination of amphotericin B and 5-flucytosine.疣状瓶霉引起的未暴露部位皮肤着色芽生菌病伴不寻常临床表现1例：两性霉素B与5-氟胞嘧啶联合治疗
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