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Effectiveness and safety of doxycycline 40 mg (30-mg immediate-release and 10-mg delayed-release beads) once daily as add-on therapy to existing topical regimens for the treatment of papulopustular rosacea: results from a community-based trial.多西环素40毫克(30毫克速释珠和10毫克缓释珠)每日一次作为现有局部治疗方案的附加疗法用于治疗丘疹脓疱型玫瑰痤疮的有效性和安全性:一项基于社区的试验结果
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The use of topical azelaic acid for common skin disorders other than inflammatory rosacea.外用壬二酸治疗除炎性酒渣鼻以外的常见皮肤病。
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本文引用的文献

1
Adult seborrheic dermatitis: a status report on practical topical management.成人脂溢性皮炎:实用局部治疗现状报告
J Clin Aesthet Dermatol. 2011 May;4(5):32-8.
2
Steroid-induced rosacea: a clinical study of 200 patients.类固醇诱导的酒渣鼻:200例患者的临床研究
Indian J Dermatol. 2011 Jan;56(1):30-2. doi: 10.4103/0019-5154.77547.
3
Perioral dermatitis.口周皮炎。
Clin Dermatol. 2011 Mar-Apr;29(2):157-61. doi: 10.1016/j.clindermatol.2010.09.007.
4
Comprehensive medical management of rosacea: an interim study report and literature review.酒渣鼻的综合医学管理:中期研究报告及文献综述
J Clin Aesthet Dermatol. 2008 May;1(1):20-5.
5
Topical calcitriol restores the impairment of epidermal permeability and antimicrobial barriers induced by corticosteroids.局部应用骨化三醇可恢复皮质类固醇诱导的表皮通透性和抗菌屏障损害。
Br J Dermatol. 2010 Jun;162(6):1251-60. doi: 10.1111/j.1365-2133.2010.09760.x. Epub 2010 Mar 10.
6
Steroid-induced periorificial dermatitis in children--clinical features and response to azelaic acid.儿童类固醇诱导的口周皮炎——临床特征及对壬二酸的反应
Pediatr Dermatol. 2010 Mar-Apr;27(2):137-42. doi: 10.1111/j.1525-1470.2009.00979.x. Epub 2009 Oct 4.
7
The use of moisturizers as an integral component of topical therapy for rosacea: clinical results based on the Assessment of Skin Characteristics Study.保湿剂作为酒渣鼻局部治疗的重要组成部分的应用:基于皮肤特征评估研究的临床结果
Cutis. 2009 Aug;84(2):72-6.
8
Anti-inflamatory dose doxycycline in the treatment of rosacea.抗炎剂量强力霉素治疗酒渣鼻
J Drugs Dermatol. 2009 Jul;8(7):664-8.
9
Steroid-induced rosacealike dermatitis: case report and review of the literature.类固醇诱导的酒渣鼻样皮炎:病例报告及文献综述
Cutis. 2009 Apr;83(4):198-204.
10
Comparison of anti-inflammatory dose doxycycline versus doxycycline 100 mg in the treatment of rosacea.抗炎剂量多西环素与100毫克多西环素治疗酒渣鼻的比较。
J Drugs Dermatol. 2008 Jun;7(6):573-6.

丘疹脓疱型酒渣鼻和口周皮炎的管理,重点关注医源性导致或加重炎症性面部皮肤病:每日一次使用40mg多西环素缓释胶囊联合适当选择的皮肤护理作为一种有效的治疗方法。

Management of Papulopustular Rosacea and Perioral Dermatitis with Emphasis on Iatrogenic Causation or Exacerbation of Inflammatory Facial Dermatoses: Use of Doxycycline-modified Release 40mg Capsule Once Daily in Combination with Properly Selected Skin Care as an Effective Therapeutic Approach.

作者信息

Rosso James Q Del

机构信息

Dermatology Residency Program Director, Valley Hospital Medical Center, Las Vegas, Nevada; Clinical Professor (Dermatology), Touro University College of Osteopathic Medicine, Henderson, Nevada; and Private Practice, Dermatology and Cutaneous Surgery, Las Vegas Skin & Cancer Clinics, Las Vegas, Nevada and Henderson, Nevada.

出版信息

J Clin Aesthet Dermatol. 2011 Aug;4(8):20-30.

PMID:21909455
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3168247/
Abstract

A variety of inflammatory facial dermatoses, such as papulopustular rosacea and perioral dermatitis, are often idiopathic. However, prolonged continuous and/or repeated intermittent topical corticosteroid use can exacerbate these disorders or, in some cases, induce them. This article discusses corticosteroid-induced rosacea-like dermatitis and primary perioral dermatitis with regard to clinical presentations, including in both adults and children, and management considerations. The rationale for use of an anti-inflammatory dose of doxycycline that is subantimicrobial, doxycycline modified-release 40mg capsule once daily, along with properly selected skin care, is discussed. Case illustrations are also included.

摘要

多种炎性面部皮肤病,如丘疹脓疱型酒渣鼻和口周皮炎,通常病因不明。然而,长期持续和/或反复间歇性外用糖皮质激素会使这些疾病加重,或在某些情况下诱发这些疾病。本文讨论了糖皮质激素诱发的酒渣鼻样皮炎和原发性口周皮炎的临床表现,包括成人和儿童的情况,以及治疗方面的考虑因素。文中还讨论了使用亚抗菌剂量的抗炎性多西环素(每日一次40mg缓释胶囊)以及正确选择皮肤护理措施的基本原理。文中还包含病例说明。