类固醇诱导的酒渣鼻：200例患者的临床研究
Steroid-induced rosacea: a clinical study of 200 patients.
作者信息
Bhat Yasmeen J, Manzoor Sheikh, Qayoom Seema
机构信息
Department of Dermatology, SKIMS Medical College Hospital, Srinagar, Jammu and Kashmir.
出版信息
Indian J Dermatol. 2011 Jan;56(1):30-2. doi: 10.4103/0019-5154.77547.
BACKGROUND
Topical corticosteroids were first introduced for use in 1951. Since then uncontrolled use (abuse) has caused many different reactions resembling rosacea - steroid dermatitis or iatrosacea. Multiple pathways including rebound vasodilatation and proinflammatory cytokine release have been proposed as the mechanism for such reactions.
AIM
The aim was to study the adverse effects of topical steroid abuse and the response to various treatment modalities.
MATERIALS AND METHODS
Two hundred patients with a history of topical steroid use on face for more than 1 month were studied clinically and various treatments tried.
RESULTS
The duration of topical corticosteroid use varied from 1 month to 20 years with an average of 19.76 months. Majority of patients were using potent (class II) topical steroids for trivial facial dermatoses. The common adverse effects were erythema, telangiectasia, xerosis, hyperpigmentation, photosensitivity, and rebound phenomenon. No significant change in laboratory investigations was seen.
CONCLUSION
A combination of oral antibiotics and topical tacrolimus is the treatment of choice for steroid-induced rosacea.
背景
外用糖皮质激素于1951年首次投入使用。从那时起，无节制使用（滥用）已导致许多类似酒渣鼻的不同反应——类固醇性皮炎或医源性酒渣鼻。包括反弹性血管扩张和促炎细胞因子释放在内的多种途径已被提出作为此类反应的机制。
目的
目的是研究外用类固醇滥用的不良反应以及对各种治疗方式的反应。
材料与方法
对200名面部外用类固醇超过1个月的患者进行临床研究，并尝试了各种治疗方法。
结果
外用糖皮质激素的使用时间从1个月到20年不等，平均为19.76个月。大多数患者因轻微面部皮肤病而使用强效（II类）外用类固醇。常见的不良反应有红斑、毛细血管扩张、皮肤干燥、色素沉着、光敏反应和反跳现象。实验室检查未见明显变化。
结论
口服抗生素和外用他克莫司联合使用是类固醇性酒渣鼻的首选治疗方法。
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