Chemical Industries Research Division, National Research Center, Dokki, Egypt.
J Mater Sci Mater Med. 2011 Nov;22(11):2545-53. doi: 10.1007/s10856-011-4437-x. Epub 2011 Sep 10.
The aim of this study was using a novel antimicrobial thermoplastic plasticizer based on aliphatic anhydride derivative dodecenyl succinic anhydride (DSA) for blending poly (vinyl chloride), PVC, with gelatin in presence of montmorillonite (MMT) using Brabender via polymer melting technique. This anhydride-based plasticizer blended the membrane ingredients homogenously under melting process. The used plasticizer exhibited high performance antimicrobial potency for some biomedical and industrial applications. The prepared biocomposite films were evaluated for antimicrobial activity using agar disc diffusion method against gram-positive and gram-negative bacteria such as: Staphylococcus aureus (S. aureus), Klebsiella pneumonia (K. pneumonia), Bacillus cereus (B. cereus), Bacillus subtilis (B. subtilis) and Escherichia coli (E. coli). The majority of these biocomposites, except the plasticized PVC with DOP, have shown inhibitory effect at different concentrations (1.0-20) mg/ml against all above mentioned bacteria. However, C. albicans and A. niger were the most resistant strains.
本研究的目的是使用基于脂肪族酸酐衍生物十二烯基琥珀酸酐（DSA）的新型抗菌热塑性增塑剂，通过 Brabender 熔融工艺，将明胶与聚氯乙烯（PVC）共混，同时使用蒙脱土（MMT）。这种酸酐基增塑剂在熔融过程中将膜成分均匀地混合在一起。所使用的增塑剂在一些生物医学和工业应用中表现出了很高的抗菌性能。通过琼脂圆盘扩散法，对制备的生物复合材料薄膜的抗菌活性进行了评估，以评估其对革兰氏阳性菌和革兰氏阴性菌（如金黄色葡萄球菌（S. aureus）、肺炎克雷伯菌（K. pneumonia）、蜡状芽孢杆菌（B. cereus）、枯草芽孢杆菌（B. subtilis）和大肠杆菌（E. coli））的抑制作用。除了用 DOP 增塑的 PVC 之外，大多数这些生物复合材料在不同浓度（1.0-20）mg/ml 下对所有上述细菌都表现出抑制作用。然而，白色念珠菌和黑曲霉是最具抗性的菌株。
