Department of Orthopaedic Surgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku, Tokyo 160-8582, Japan.
Neurotherapeutics. 2011 Oct;8(4):668-76. doi: 10.1007/s13311-011-0063-z.
Reports of functional recovery from spinal cord injury after the transplantation of rat fetus-derived neural stem cells and embryonic stem cells has raised great expectations for the successful clinical use of stem cell transplantation therapy. However, the ethical issues involved in destroying human embryos or fertilized oocytes to obtain stem cells have been a major obstacle to developing clinically useful stem cell sources, and the transplantation of stem cells isolated from other human embryonic tissues has not yet been developed for use in clinical applications. Recently, induced pluripotent stem cells, which can serve as a source of cells for autologous transplantation, have been attracting a great deal of attention as a clinically viable alternative to stem cells obtained directly from tissues. In this review, we outline the neural induction of mouse embryonic stem cells and induced pluripotent stem cells, their therapeutic efficacy in spinal cord injury, and their safety in vivo.
报告称，在移植大鼠胎源性神经干细胞和胚胎干细胞后，脊髓损伤功能得到恢复，这为成功临床应用干细胞移植治疗带来了巨大希望。然而，在获取干细胞过程中破坏人类胚胎或受精卵所涉及的伦理问题一直是开发临床有用的干细胞来源的主要障碍，而从其他人类胚胎组织中分离的干细胞的移植尚未开发用于临床应用。最近，诱导多能干细胞作为自体移植细胞的来源，作为直接从组织中获得的干细胞的一种可行的临床替代方法，引起了极大的关注。在这篇综述中，我们概述了小鼠胚胎干细胞和诱导多能干细胞的神经诱导，它们在脊髓损伤中的治疗效果及其体内安全性。
