Department of Gastroenterology, Huai'an No 1 Hospital, Nanjing Medical University, Huai'an, 223300 Jiangsu, China.
Med Oncol. 2012 Sep;29(3):1733-8. doi: 10.1007/s12032-011-0061-3. Epub 2011 Sep 11.
The neural precursor cell expressed, developmentally down-regulated 4-like (Nedd4L) gene encodes an ubiquitin ligase that targets the epithelial sodium channel for degradation. Recent studies have demonstrated that Nedd4L plays a role in the progression of various cancers. However, the clinical implications of Nedd4L expression status in gastric cancer have remained unclear. We examined the Nedd4L expression in 82 gastric cancer patients by immunohistochemistry. The correlation between Nedd4L expression and clinicopathological factors, including prognosis, was evaluated. Cancerous Nedd4L expression was detectable in 36 of the 82 tumors (43.9%). Tumors with negative Nedd4L expression had greater extent of lymph node metastasis, lymphatic invasion, and venous invasion, and were at a worse stage than the tumors with positive Nedd4L expression. Additionally, the patients with negative Nedd4L expression had poor clinical outcomes. Furthermore, multivariate analysis indicated that Nedd4L expression was an independent prognostic factor for gastric cancer patients. Our results suggest for the first time that negative Nedd4L expression is strongly related to the invasion and metastasis of gastric cancer. Therefore, Nedd4L expression can be used as an independent prognostic marker of gastric cancer.
神经前体细胞表达的发育下调 4 样蛋白（Nedd4L）基因编码一种泛素连接酶，可靶向降解上皮钠通道。最近的研究表明，Nedd4L 在多种癌症的进展中发挥作用。然而，Nedd4L 表达状态在胃癌中的临床意义仍不清楚。我们通过免疫组织化学法检测了 82 例胃癌患者的 Nedd4L 表达情况。评估了 Nedd4L 表达与临床病理因素（包括预后）之间的相关性。在 82 个肿瘤中，有 36 个（43.9%）可检测到癌性 Nedd4L 表达。与 Nedd4L 阳性表达的肿瘤相比，Nedd4L 阴性表达的肿瘤具有更大的淋巴结转移、淋巴侵袭和静脉侵袭程度，且处于更差的分期。此外，Nedd4L 阴性表达的患者临床结局较差。此外，多因素分析表明，Nedd4L 表达是胃癌患者的独立预后因素。我们的研究结果首次表明，Nedd4L 阴性表达与胃癌的侵袭和转移密切相关。因此，Nedd4L 表达可以作为胃癌的独立预后标志物。
