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全关节镜下 AMIC 手术治疗膝关节软骨缺损。

All-arthroscopic AMIC procedure for repair of cartilage defects of the knee.

机构信息

Rehasport Clinic, ul. Górecka 30, 60-201, Poznan, Poland.

出版信息

Knee Surg Sports Traumatol Arthrosc. 2012 May;20(5):922-5. doi: 10.1007/s00167-011-1657-z. Epub 2011 Sep 11.

DOI:10.1007/s00167-011-1657-z
PMID:21910000
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3332359/
Abstract

PURPOSE

Bone marrow mesenchymal stem cells were introduced into clinical practice due to their ability to differentiate into many types of cells. Autologous matrix-induced chondrogenesis (AMIC) combines the microfracture method with matrix-based techniques that utilizes a collagen membrane to serve as a scaffold for new bone marrow mesenchymal stem cells, allowing effective reconstruction of even large fragments of a damaged cartilage surface.

METHODS

All-arthroscopic technique to repair knee cartilage defects using the AMIC technique, which includes the use of a collagen matrix (porcine collagen type I and III) and fibrin glue-technique presentation.

CONCLUSION

This technical note introduces an all-arthroscopic AMIC technique to reconstruct extensive cartilage defects (without bone defects). The technique may be used for treatment of all location of knee cartilage lesions.

LEVEL OF EVIDENCE

V.

摘要

目的

骨髓间充质干细胞因其能够分化为多种类型的细胞而被引入临床实践。自体基质诱导软骨形成术(AMIC)将微骨折方法与基于基质的技术相结合,利用胶原膜作为新的骨髓间充质干细胞的支架,从而有效重建即使是受损软骨表面的大块碎片。

方法

采用 AMIC 技术的全关节镜技术修复膝关节软骨缺损,包括使用胶原基质(猪Ⅰ型和Ⅲ型胶原)和纤维蛋白胶技术。

结论

本技术说明介绍了一种全关节镜 AMIC 技术来重建广泛的软骨缺损(无骨缺损)。该技术可用于治疗膝关节软骨损伤的所有部位。

证据等级

V。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ba5/3332359/4ad945e3609c/167_2011_1657_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ba5/3332359/581e37511e09/167_2011_1657_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ba5/3332359/b65fd5630f34/167_2011_1657_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ba5/3332359/8983582b298b/167_2011_1657_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ba5/3332359/4ad945e3609c/167_2011_1657_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ba5/3332359/581e37511e09/167_2011_1657_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ba5/3332359/b65fd5630f34/167_2011_1657_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ba5/3332359/8983582b298b/167_2011_1657_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ba5/3332359/4ad945e3609c/167_2011_1657_Fig4_HTML.jpg

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Autologous Matrix-Induced Chondrogenesis (AMIC): Combining Microfracturing and a Collagen I/III Matrix for Articular Cartilage Resurfacing.自体基质诱导软骨生成术(AMIC):联合微骨折术和 I/III 型胶原基质进行关节软骨表面重建。
Cartilage. 2010 Jan;1(1):65-8. doi: 10.1177/1947603509360044.
2
Prone position for minimal invasive or all-arthroscopic autologous chondrocyte implantation at the patella.髌骨下微创或全关节镜下自体软骨细胞移植的俯卧位。
Knee Surg Sports Traumatol Arthrosc. 2011 Dec;19(12):2036-9. doi: 10.1007/s00167-011-1505-1. Epub 2011 Apr 9.
3
The treatment of chondral and osteochondral defects of the knee with autologous matrix-induced chondrogenesis (AMIC): method description and recent developments.
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Knee Surg Sports Traumatol Arthrosc. 2025 Jun;33(6):2104-2113. doi: 10.1002/ksa.12518. Epub 2024 Oct 28.
4
Supratrochlear Rim is Correlated with Isolated Patellar Chondromalacia on Magnetic Resonance Imaging of the Knee.在膝关节磁共振成像中,滑车上缘与孤立性髌软骨软化相关。
Arthrosc Sports Med Rehabil. 2024 Feb 1;6(2):100855. doi: 10.1016/j.asmr.2023.100855. eCollection 2024 Apr.
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Positive outcomes following Autologous Matrix-Induced Chondrogenesis (AMIC) in the treatment of retropatellar chondral lesions: a retrospective analysis of a patient registry.自体诱导多能干细胞软骨生成术(AMIC)治疗髌前软骨病变的疗效:患者注册登记的回顾性分析。
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Knee Surg Sports Traumatol Arthrosc. 2005 Apr;13(3):213-21. doi: 10.1007/s00167-004-0499-3. Epub 2004 May 14.