School of Chemistry, Madurai Kamaraj University, Madurai 625021, India.
J Org Chem. 2011 Nov 4;76(21):9090-5. doi: 10.1021/jo201261w. Epub 2011 Oct 5.
A simple and efficient route for the synthesis of 5-substituted 1H-tetrazoles catalyzed by CoY zeolite is reported. The salient features of this atom-economical, cost-effective, and high-yield cobalt-catalyzed protocol are aerobic conditions, lower reaction time, and milder reaction conditions without additives. Other advantages include experimental ease of manipulation, safer alternative to hazardous, corrosive, and polluting conventional Lewis acid catalysts, recovery, and reusability with consistent catalytic activity. The results are rationalized by proposing a suitable mechanism.
报道了一种由 CoY 沸石催化的 5-取代 1H-四唑的合成的简单高效的路线。该原子经济性、成本效益高且钴催化产率高的协议的突出特点是有氧条件、较短的反应时间和较温和的反应条件，无需添加任何助剂。其他优点包括实验操作简便、替代危险、腐蚀性和污染性传统路易斯酸催化剂、回收和再利用以及一致的催化活性。通过提出合适的机制，对结果进行了合理化解释。
