Department of Radiology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA.
J Nucl Med. 2011 Oct;52(10):1501-4. doi: 10.2967/jnumed.111.097683. Epub 2011 Sep 12.
Understanding the distinct molecular features of solid tumors provides the opportunity to develop more targeted and effective therapies. The evaluation and monitoring of these therapies require sophisticated laboratory and imaging technologies to detect potential benefit not necessarily translating into significant changes in tumor size. PET has emerged as the most sensitive imaging technique for providing the metabolic profile of an individual tumor. Most recently, the detection of circulating tumor cells in the peripheral blood of patients with advanced malignancies has provided another dimension to the use of PET for sensitive therapeutic monitoring. Moreover, molecular characterization of circulating tumor cells holds promise for furthering the care of cancer patients.
了解实体瘤的独特分子特征为开发更具针对性和更有效的治疗方法提供了机会。这些疗法的评估和监测需要复杂的实验室和成像技术，以检测潜在的益处，而这些益处不一定转化为肿瘤大小的显著变化。PET 已成为提供个体肿瘤代谢特征的最敏感成像技术。最近，在晚期恶性肿瘤患者的外周血液中检测循环肿瘤细胞为 PET 进行敏感治疗监测提供了另一个维度。此外，循环肿瘤细胞的分子特征有望进一步改善癌症患者的护理。
