Department of Urology, Herlev Hospital, University of Copenhagen, Herlev, Denmark.
Spinal Cord. 2012 Jan;50(1):63-6. doi: 10.1038/sc.2011.101. Epub 2011 Sep 13.
Retrospective cohort study.
Anejaculation is commonly found in spinal cord injured (SCI) men. Clinical treatments and assisted reproductive techniques allow SCI men to father children but few home pregnancies have been reported. The objective of this paper is to evaluate the results from the last 20 years' of treatment with penile vibratory stimulation (PVS) and vaginal self-insemination at home in SCI men and their partners.
The data originate from two European centers and one American center.
A total of 140 SCI men with anejaculation and their healthy partners were available for this analysis. Men who obtained antegrade ejaculation by PVS and had motile sperm in the ejaculate were offered the possibility of PVS combined with vaginal self-insemination at home. Couples were instructed to perform PVS and to instill the ejaculate intravaginally. Outcome measures were pregnancy rate per couple, number of live births, total motile sperm count and time to pregnancies.
Median total motile sperm count was 29 million (range, 1-92 million). In all, 60 of the 140 couples (43% pregnancy rate) achieved 82 pregnancies. Seventy-two of the pregnancies resulted in live births with the delivery of 73 healthy babies. Median time to first pregnancy was 22.8 months (6.0-98.4). No complications were reported.
PVS combined with vaginal self-insemination may be performed as a viable, inexpensive option for assisted conception in couples in whom the SCI male partner has an adequate total motile sperm count and the female partner is healthy.
回顾性队列研究。
射精障碍在脊髓损伤(SCI)男性中较为常见。临床治疗和辅助生殖技术使 SCI 男性能够生育子女,但很少有家庭怀孕的报道。本文的目的是评估过去 20 年来使用阴茎振动刺激(PVS)和在家中进行阴道自我授精治疗 SCI 男性及其伴侣的结果。
数据来自两个欧洲中心和一个美国中心。
共有 140 名患有射精障碍的 SCI 男性及其健康伴侣可用于此项分析。通过 PVS 获得顺行射精且精液中有活动精子的男性,可获得 PVS 联合在家中进行阴道自我授精的机会。夫妇接受 PVS 指导,并将精液注入阴道。评估指标为每对夫妇的妊娠率、活产数、总活动精子数和妊娠时间。
中位总活动精子数为 2900 万(范围,1-9200 万)。140 对夫妇中有 60 对(43%的妊娠率)成功怀孕 82 次。72 次妊娠导致 73 名健康婴儿的活产。首次妊娠的中位时间为 22.8 个月(6.0-98.4)。未报告任何并发症。
对于精子总数足够且女性伴侣健康的 SCI 男性及其伴侣,PVS 联合阴道自我授精可作为一种可行且经济的辅助受孕选择。