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Rifamycin B 产生菌地中海拟无枝酸菌 S699 的全基因组序列。

Whole genome sequence of the rifamycin B-producing strain Amycolatopsis mediterranei S699.

机构信息

Department of Zoology, University of Delhi, Delhi 110 007, India.

出版信息

J Bacteriol. 2011 Oct;193(19):5562-3. doi: 10.1128/JB.05819-11.

DOI:10.1128/JB.05819-11
PMID:21914879
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3187414/
Abstract

Amycolatopsis mediterranei S699 is an actinomycete that produces an important antibiotic, rifamycin B. Semisynthetic derivatives of rifamycin B are used for the treatment of tuberculosis, leprosy, and AIDS-related mycobacterial infections. Here, we report the complete genome sequence (10.2 Mb) of A. mediterranei S699, with 9,575 predicted coding sequences.

摘要

地中海拟无枝酸菌 S699 是一种放线菌，能够产生一种重要的抗生素——利福霉素 B。利福霉素 B 的半合成衍生物被用于治疗结核病、麻风病和艾滋病相关分枝杆菌感染。在此，我们报道了地中海拟无枝酸菌 S699 的全基因组序列（10.2 Mb），其中预测有 9575 个编码序列。

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本文引用的文献

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Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism. Rifamycin SV 产生菌地中海拟无枝酸菌 U32 的全基因组序列揭示了其在系统发育和代谢中的遗传特征。
Cell Res. 2010 Oct;20(10):1096-108. doi: 10.1038/cr.2010.87. Epub 2010 Jun 22.
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Identification of tailoring genes involved in the modification of the polyketide backbone of rifamycin B by Amycolatopsis mediterranei S699.鉴定由地中海拟无枝酸菌S699参与修饰利福霉素B聚酮骨架的定制基因。
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