人工核酸酶的多组分合成及其 RNase 和 DNase 活性。

Department of Chemistry, Moscow State University, 119992, Leninskie Gory, Moscow, Russia.

Beilstein J Org Chem. 2011;7:1135-40. doi: 10.3762/bjoc.7.131. Epub 2011 Aug 19.

The synthesis of new, artificial ribonucleases containing two amino acid residues connected by an aliphatic linker has been developed. Target molecules were synthesized via a catalytic three-component Ugi reaction from aliphatic diisocyanides. Preliminary investigations proved unspecific nuclease activity of the new compounds towards single-stranded RNA and double-stranded circular DNA.

已开发出含有通过脂族连接子连接的两个氨基酸残基的新型人工核糖核酸酶的合成方法。目标分子是通过脂肪族二异氰酸酯的催化三组分 Ugi 反应合成的。初步研究证明，新型化合物对单链 RNA 和双链环状 DNA 具有非特异性核酸酶活性。