铜（I）催化的乙烯基卤化物与炔烃的偶联或乙烯基卤化物的串联偶联反应合成 1,3-烯炔。

Copper(I)-catalyzed synthesis of 1,3-enynes via coupling between vinyl halides and alkynes or domino coupling of vinyl halides.

机构信息

Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, P. R. China.

出版信息

Org Biomol Chem. 2011 Nov 7;9(21):7309-12. doi: 10.1039/c1ob06210g. Epub 2011 Sep 14.

DOI:10.1039/c1ob06210g

PMID:21915420

Abstract

1,3-Enynes were easily prepared from coupling between vinyl halides and alkynes or domino coupling of vinyl halides in the presence of copper iodide. It is noteworthy that the double-bond geometry of the vinyl halides was retained during the reaction. This ligand-free protocol is potentially useful and practical.

摘要

1,3-烯炔很容易通过乙烯基卤化物与炔烃的偶联或在碘化亚铜存在下的乙烯基卤化物的多米诺偶联来制备。值得注意的是，在反应过程中，乙烯基卤化物的双键几何形状得以保留。该无配体的方案具有潜在的有用性和实用性。