Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, 100084 China.
J Org Chem. 2009 Aug 21;74(16):6371-3. doi: 10.1021/jo901105r.
A copper-catalyzed methodology for the coupling of vinyl bromides with azoles has been developed. This protocol uses a combination of 10 mol % of copper iodide and 20 mol % of ethylenediamine as catalyst. The reaction proceeds with various azoles and vinyl bromides, and the double bond geometry of vinyl bromides is retained under the reaction conditions.
一种铜催化的溴乙烯与唑类化合物偶联的方法已经被开发出来。该方法使用 10 mol%的碘化亚铜和 20 mol%的乙二胺作为催化剂。该反应可以与各种唑类化合物和溴乙烯进行反应，并且在反应条件下溴乙烯的双键几何构型得以保留。
