Beverley P C
Imperial Cancer Research Fund, Human Tumour Immunology Group, London, UK.
Immunol Today. 1990 Jun;11(6):203-5. doi: 10.1016/0167-5699(90)90083-l.
Whether or not T- and B-cell memory is antigen driven remains unresolved. Recent studies indicate that, in humans, naive and memory T cells can be distinguished by their expression of different CD45 isoforms. Extensive phenotypic analysis of naive and memory T cells shows that the latter express greater amounts of several adhesion molecules as well as low levels of several antigens indicative of activation. These features suggest to Peter Beverley that memory T cells may be more readily activated and that memory may be maintained by crossreactive restimulation.
T细胞和B细胞记忆是否由抗原驱动仍未得到解决。最近的研究表明，在人类中，初始T细胞和记忆T细胞可以通过它们表达的不同CD45异构体来区分。对初始T细胞和记忆T细胞进行的广泛表型分析表明，后者表达大量的几种黏附分子以及低水平的几种指示激活的抗原。这些特征向彼得·贝弗利表明，记忆T细胞可能更容易被激活，并且记忆可能通过交叉反应性再刺激得以维持。
