B细胞在维持辅助性T细胞记忆中的作用。
Role of B cells in maintaining helper T-cell memory.
作者信息
van Essen D, Dullforce P, Gray D
机构信息
Institute of Cell, Animal and Population Biology, University of Edinburgh, Ashworth Laboratories, UK.
出版信息
Philos Trans R Soc Lond B Biol Sci. 2000 Mar 29;355(1395):351-5. doi: 10.1098/rstb.2000.0572.
Abstract
The cellular interactions involved in maintaining CD4+ T-cell memory have hitherto not been identified. In this report, we have investigated the role played by B cells in this process. We show that that long-lasting helper T-cell memory depends on the presence of B cells, but that direct antigen presentation by B cells is not required. These findings provide new insights into the mechanisms which underlie helper T-cell memory. They also suggest that the efficacy of future vaccines will depend critically on the inclusion of B- as well as T-cell epitopes.
摘要
迄今为止，维持CD4+ T细胞记忆所涉及的细胞间相互作用尚未明确。在本报告中，我们研究了B细胞在此过程中所起的作用。我们发现，持久的辅助性T细胞记忆依赖于B细胞的存在，但并不需要B细胞直接呈递抗原。这些发现为辅助性T细胞记忆的潜在机制提供了新的见解。它们还表明，未来疫苗的效力将严重依赖于同时包含B细胞表位和T细胞表位。
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