脑垂体中表皮生长因子受体家族及其配体的表达与功能
Expression and function of ErbB receptors and ligands in the pituitary.
机构信息
Department of Medicine, Pituitary Center, Cedars-Sinai Medical Center, Academic Affairs, Room 2015, 8700 Beverly Boulevard, Los Angeles, California 90048, USA.
出版信息
Endocr Relat Cancer. 2011 Oct 27;18(6):R197-211. doi: 10.1530/ERC-11-0066. Print 2011 Oct.
Abstract
The role of ErbB family in discreet pituitary functions is reviewed. Several ErbB receptor ligands, EGF, TGFα, and heregulin are differentially expressed in normal gonadotroph and lacto-somatotroph lineages, and other elements of the anterior pituitary. ErbB receptors, i.e. EGFR and ErbB2, are also localized to the anterior pituitary with preferential EGFR lactosomatotroph expression. EGF regulates CRH and ACTH secretion and corticotroph proliferation as well as exhibiting autocrine and paracrine effects on gonadotrophs and on lactosomatotroph proliferation, gene and protein expression, and hormonal secretion. EGF and EGFR are expressed in both functioning and non-functioning pituitary adenomas, with higher expression in more aggressive tumor subtypes. ErbB2 receptor is detected in all tumor subtypes, particularly in invasive tumors. ErbB tyrosine kinase inhibitors regulate hormonal secretion, cell morphology, and proliferation in lacto-somatotroph tumors, reflecting the emerging application of targeted pituitary therapeutics.
摘要
本文回顾了 ErbB 家族在垂体功能中的作用。几种 ErbB 受体配体，如表皮生长因子（EGF）、转化生长因子-α（TGFα）和人表皮生长因子受体 3（HER3）配体神经调节蛋白（NRG），在正常的促性腺激素和催乳生长激素细胞系以及垂体前叶的其他成分中呈差异表达。ErbB 受体，即表皮生长因子受体（EGFR）和 HER2，也定位于垂体前叶，其中 EGFR 在催乳生长激素细胞中优先表达。EGF 调节促肾上腺皮质激素释放激素（CRH）和促肾上腺皮质激素（ACTH）的分泌和促肾上腺皮质激素细胞的增殖，并且对促性腺激素和催乳生长激素细胞的增殖、基因和蛋白表达以及激素分泌具有自分泌和旁分泌作用。EGF 和 EGFR 在前叶功能性和非功能性腺瘤中均有表达，在侵袭性肿瘤亚型中表达更高。所有肿瘤亚型中均可检测到 ErbB2 受体，特别是在侵袭性肿瘤中。ErbB 酪氨酸激酶抑制剂调节催乳生长激素细胞瘤的激素分泌、细胞形态和增殖，反映了靶向垂体治疗的应用日益广泛。
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需注意，你原文中的“heregulin”可能有误，通常该词是“heregulin”，常见的中文译名是“赫赛汀” ，它是一种与肿瘤发生、发展等相关的因子。按照准确的内容，这段英文的准确译文应该是：
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