Donaldson J D, Martin G F, Maltby C C, Seywerd E B
Department of Otolaryngology, Izaak Walton Killam Hospital for Children, Halifax, Nova Scotia, Canada.
J Otolaryngol. 1990 Jun;19(3):175-8.
Consensus has been achieved supporting the efficacy of antimicrobials in the management of acute otitis media with effusion (OME). No such agreement has been reached into medical management of the patient in whom middle ear effusion (MEE) persists beyond the conventional 10- to 14-day treatment cycle. This study is designed to demonstrate the efficacy of antibiotics administered in a single daily dose in the management of persistent otitis media with effusion (POME). Seventy-nine subjects who had MEE in 116 ears after conventional therapy were randomized into medication and placebo groups and followed by the authors on a blinded basis. The results demonstrate the efficacy of pulse-dosed antibiotics in the management of POME. Prevention of relapses during therapy was responsible for the superior outcome for children in the treatment group.
对于抗菌药物在治疗急性分泌性中耳炎（OME）中的疗效已达成共识。对于中耳积液（MEE）在传统的10至14天治疗周期后仍持续存在的患者，在药物治疗方面尚未达成此类共识。本研究旨在证明每日单次剂量使用抗生素治疗持续性分泌性中耳炎（POME）的疗效。79名在接受传统治疗后116耳存在MEE的受试者被随机分为用药组和安慰剂组，并由作者进行盲法跟踪。结果证明了脉冲给药抗生素在治疗POME方面的疗效。治疗期间预防复发是治疗组儿童取得更好疗效的原因。
