Department of Neurology, Kaohsiung Medical University Hospital, Taiwan.
Am J Alzheimers Dis Other Demen. 2011 Sep;26(6):457-62. doi: 10.1177/1533317511421779. Epub 2011 Sep 15.
Relationship between late-life hypertension and Alzheimer's disease (AD) remains less clear. Both cross-sectional and longitudinal methods were used to examine whether systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure (PP), mean arterial pressure (MAP), and self-reported hypertension (S-HTN) in late life were associated with having and developing AD. The cross-sectional examination included 1768 individuals with AD and 818 nondemented individuals, and AD was not significantly associated with S-HTN or any of blood pressure measures (S-HTN: P = .236; SBP: P = .095; DBP: P = .429; PP: P = .145; MAP: P = .162). In the longitudinal examination, 594 nondemented individuals, 171 with and 423 without S-HTN at entry, were included. Diastolic blood pressure was significantly related to the development of AD (P = .030) but not S-HTN (P = .251), SBP (P = .294) PP (P = .919), and MAP (P = .060). The association underscores the necessity of further investigation to outline the detailed mechanisms and biological relevance, if any, of late-life DBP to later AD.
老年期高血压与阿尔茨海默病（AD）之间的关系仍不明确。本研究采用横断面和纵向方法，旨在探讨老年期收缩压（SBP）、舒张压（DBP）、脉压（PP）、平均动脉压（MAP）和自我报告的高血压（S-HTN）与 AD 发生和发展的关系。横断面研究共纳入 1768 例 AD 患者和 818 例非痴呆患者，AD 与 S-HTN 或任何血压指标均无显著相关性（S-HTN：P =.236；SBP：P =.095；DBP：P =.429；PP：P =.145；MAP：P =.162）。在纵向研究中，纳入了 594 例非痴呆患者，其中 171 例在入组时患有 S-HTN，423 例未患 S-HTN。DBP 与 AD 的发生显著相关（P =.030），但 S-HTN（P =.251）、SBP（P =.294）、PP（P =.919）和 MAP（P =.060）与 AD 的发生无关。该结果强调了进一步研究的必要性，以阐明老年期 DBP 与后期 AD 之间的详细机制和生物学相关性。
