Ren Li, Bai Lingling, Wu Yanan, Ni Jingxian, Shi Min, Lu Hongyan, Tu Jun, Ning Xianjia, Lei Ping, Wang Jinghua
Department of Neurology, Tianjin Medical University General Hospital, Tianjin, China.
Tianjin Neurological Institute, Key Laboratory of Post-Neuroinjury Neuro-Repair and Regeneration in Central Nervous System, Ministry of Education and Tianjin City, Tianjin, China.
Front Aging Neurosci. 2018 Mar 28;10:62. doi: 10.3389/fnagi.2018.00062. eCollection 2018.
This study aimed to evaluate the prevalence of cognitive impairment and the distribution of its risk factors among residents aged ≥60 years without cardiovascular and cerebrovascular diseases in rural areas of northern China screened with the Chinese version of the Mini-Mental State Examination (MMSE). Between 2012 and 2013, a questionnaire survey was conducted to collect basic information from participants. Cognitive function was assessed using the MMSE. In the univariate analysis, risk factors for cognitive disorders were female sex, low education and central obesity, while drinking was found to be a protective factor. In the multivariate analysis, risk factors were old age (odds ratio [OR], 1.888; 95% confidence interval [CI]: 1.256-2.838; = 0.002 for the 70-year-old group compared with the 60-year-old group; OR, 3.593; 95% CI, 2.468-5.230; < 0.001 for the ≥75-year-old group compared with the 60-year-old group), low education (OR, 3.779; 95% CI: 2.218-6.440; < 0.001 for the illiterate group compared with the group with ≥9 years of education; OR, 1.667; 95% CI, 1.001-2.775; = 0.05 for the group with less than primary school compared with the group with ≥9 years of education), and higher blood pressure (BP; OR, 1.655; 95% CI: 1.076-2.544; = 0.002 for individuals with stage III hypertension compared with those with normal BP). These findings suggest that it is crucial to manage and control level of BP, and improve educational attainment in order to reduce the prevalence and burden of cognitive impairment among low-income residents in rural China.
本研究旨在评估在中国北方农村地区年龄≥60岁且无心血管和脑血管疾病的居民中，使用中文版简易精神状态检查表（MMSE）筛查出的认知障碍患病率及其危险因素分布情况。在2012年至2013年期间，进行了问卷调查以收集参与者的基本信息。使用MMSE评估认知功能。在单因素分析中，认知障碍的危险因素为女性、低教育水平和中心性肥胖，而饮酒被发现是一个保护因素。在多因素分析中，危险因素为高龄（比值比[OR]，1.888；95%置信区间[CI]：1.256 - 2.838；70岁组与60岁组相比，P = 0.002；≥75岁组与60岁组相比，OR，3.593；95% CI，2.468 - 5.230；P < 0.001）、低教育水平（文盲组与受教育≥9年组相比，OR，3.779；95% CI：2.218 - 6.440；P < 0.001；小学以下组与受教育≥9年组相比，OR，1.667；95% CI，1.001 - 2.775；P = 0.05）以及较高的血压（BP；III期高血压患者与血压正常者相比，OR，1.655；95% CI：1.076 - 2.544；P = 0.002）。这些研究结果表明，控制血压水平并提高教育程度对于降低中国农村低收入居民认知障碍的患病率和负担至关重要。
