Department of Oral Microbiology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Virulence. 2011 Sep-Oct;2(5):427-30. doi: 10.4161/viru.2.5.17711. Epub 2011 Sep 1.
Two-component systems (TCSs) play important roles in the adaptation of bacteria to environmental changes and the regulation of virulence factor expression. In addition, the association of TCSs with susceptibility to antibacterial agents has been demonstrated in some bacterial species. Staphylococcus aureus, a major human pathogen that can cause serious problems due to nosocomial infections, possesses 16 TCSs. Here we report a TCS, designated BceRS (MW2 gene ID: MW2545-44), which is related to bacitracin susceptibility. We found that BceRS regulates the expression of two transporters that determine susceptibility to bacitracin. One of these, BceAB (MW2543-42), is located downstream of BceRS, while the other, VraDE (MW2620-21), is more distant. With regard to other TCSs, VraRS and Aps/GraRS are reportedly associated with susceptibility to cell wall synthesis inhibitors and cationic antibacterial agents, respectively. Therefore, S. aureus possesses at least three TCSs that are involved in mediating its resistance to antibacterial agents.
双组分系统（TCSs）在细菌适应环境变化和调节毒力因子表达方面发挥着重要作用。此外，一些细菌物种中已经证明 TCSs 与对抗菌药物的敏感性有关。金黄色葡萄球菌是一种主要的人类病原体，由于医院感染，可能会导致严重的问题，它拥有 16 个 TCSs。在这里，我们报告了一个 TCS，命名为 BceRS（MW2 基因 ID：MW2545-44），它与杆菌肽敏感性有关。我们发现 BceRS 调节两个决定杆菌肽敏感性的转运蛋白的表达。其中一个，BceAB（MW2543-42），位于 BceRS 下游，而另一个，VraDE（MW2620-21），则更远。关于其他 TCSs，据报道 VraRS 和 Aps/GraRS 分别与细胞壁合成抑制剂和阳离子抗菌药物的敏感性有关。因此，金黄色葡萄球菌至少拥有三个 TCSs，它们参与介导其对抗菌药物的耐药性。
