Wu Shizhou, Lin Kaifeng, Liu Yunjie, Zhang Hui, Lei Lei
Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
Biomed Rep. 2020 Aug;13(2):5. doi: 10.3892/br.2020.1312. Epub 2020 Jun 9.
As the issues surrounding antibiotic-resistant strains of () are becoming increasingly serious concerns, it is imperative to investigate new therapeutic targets to successfully treat patients with infections. The two-component signal transduction system is one of the primary pathways by which bacteria adapt to the external environment, and it serves an important role in regulating virulence gene expression, cell wall synthesis, biofilm formation and bacterial activity. There are 17 two-component signaling pathways in , among which WalKR/VicSR/YycGF, AirSR/YhcSR, vancomycin resistance associated regulator/sensor and LytRS have been demonstrated to serve vital roles in regulating bacterial resistance, and are hypothesized to be potential targets for the treatment of infections. The present review assesses the mechanism of the two-component signaling pathways associated with the development of resistance.
随着围绕（）抗生素耐药菌株的问题日益受到严重关注，研究新的治疗靶点以成功治疗（）感染患者势在必行。双组分信号转导系统是细菌适应外部环境的主要途径之一，在调节毒力基因表达、细胞壁合成、生物膜形成和细菌活性方面发挥着重要作用。（）中有17条双组分信号通路，其中WalKR/VicSR/YycGF、AirSR/YhcSR、万古霉素耐药相关调节因子/传感器和LytRS已被证明在调节细菌耐药性中发挥重要作用，并被假定为治疗（）感染的潜在靶点。本综述评估了与（）耐药性发展相关的双组分信号通路的机制。
