发育调控的可变剪接的功能后果。
Functional consequences of developmentally regulated alternative splicing.
机构信息
Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas 77030, USA.
出版信息
Nat Rev Genet. 2011 Sep 16;12(10):715-29. doi: 10.1038/nrg3052.
Abstract
Genome-wide analyses of metazoan transcriptomes have revealed an unexpected level of mRNA diversity that is generated by alternative splicing. Recently, regulatory networks have been identified through which splicing promotes dynamic remodelling of the transcriptome to promote physiological changes, which involve robust and coordinated alternative splicing transitions. The regulation of splicing in yeast, worms, flies and vertebrates affects a variety of biological processes. The functional classes of genes that are regulated by alternative splicing include both those with widespread homeostatic activities and those with cell-type-specific functions. Alternative splicing can drive determinative physiological change or can have a permissive role by providing mRNA variability that is used by other regulatory mechanisms.
摘要
真核生物转录组的全基因组分析揭示了一种令人惊讶的 mRNA 多样性，这种多样性是由可变剪接产生的。最近，已经鉴定出调控网络，通过这些调控网络，剪接促进转录组的动态重塑，从而促进涉及强大和协调的可变剪接转变的生理变化。酵母、蠕虫、苍蝇和脊椎动物中剪接的调节影响多种生物学过程。受可变剪接调节的基因的功能类别包括具有广泛的稳态活性的基因和具有细胞类型特异性功能的基因。可变剪接可以通过提供其他调节机制使用的 mRNA 可变性来驱动决定性的生理变化，或者通过发挥允许性作用来发挥作用。
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