Foster Erin R, Hershey Tamara
Program in Occupational Therapy and Departments of Psychiatry and Neurology, Washington University in St. Louis School of Medicine, St. Louis, Missouri.
OTJR (Thorofare N J). 2011;31(1):16-22. doi: 10.3928/15394492-20101108-04.
Individuals with Parkinson disease (PD) who do not have dementia reliably demonstrate mild executive deficits on laboratory-based tests, but the impact of these deficits on occupational performance is unclear. The purpose of this study was to determine the relevance of executive dysfunction in PD without dementia to instrumental, leisure, and social activity participation. Twenty-four individuals with PD and 30 matched adult volunteers performed an experimental working memory test and rated their everyday executive function and activity participation. Participants with PD had worse working memory performance, tended to report more everyday executive problems, and reported lower activity participation compared to controls. Within PD, lower everyday executive function was associated with reduced activity participation after controlling for motor dysfunction and depressive symptoms. Executive function is an independent predictor of complex activity participation in early PD. These results suggest the need for occupational therapists to consider executive dysfunction during evaluation and treatment of individuals with PD.
没有痴呆症的帕金森病（PD）患者在基于实验室的测试中确实表现出轻度执行功能缺陷，但这些缺陷对职业表现的影响尚不清楚。本研究的目的是确定无痴呆症的PD患者执行功能障碍与工具性、休闲和社交活动参与之间的相关性。24名PD患者和30名匹配的成年志愿者进行了一项实验性工作记忆测试，并对他们日常的执行功能和活动参与情况进行了评分。与对照组相比，PD患者的工作记忆表现更差，往往报告更多日常执行问题，且活动参与度更低。在PD患者中，在控制了运动功能障碍和抑郁症状后，较低的日常执行功能与活动参与度降低有关。执行功能是早期PD患者复杂活动参与的独立预测因素。这些结果表明，职业治疗师在评估和治疗PD患者时需要考虑执行功能障碍。
