School of Forensic and Investigative Sciences, University of Central Lancashire, Preston, Lancashire, United Kingdom.
Med Res Rev. 2013 Jan;33(1):190-234. doi: 10.1002/med.20252. Epub 2011 Sep 15.
Here, we review potential determinants of the anticancer efficacy of innate immune peptides (ACPs) for cancer cells. These determinants include membrane-based factors, such as receptors, phosphatidylserine, sialic acid residues, and sulfated glycans, and peptide-based factors, such as residue composition, sequence length, net charge, hydrophobic arc size, hydrophobicity, and amphiphilicity. Each of these factors may contribute to the anticancer action of ACPs, but no single factor(s) makes an overriding contribution to their overall selectivity and toxicity. Differences between the anticancer actions of ACPs seem to relate to different levels of interplay between these peptide and membrane-based factors.
在这里，我们回顾了先天免疫肽（ACPs）对癌细胞抗癌功效的潜在决定因素。这些决定因素包括基于膜的因素，如受体、磷脂酰丝氨酸、唾液酸残基和硫酸化聚糖，以及基于肽的因素，如残基组成、序列长度、净电荷、疏水性弧大小、疏水性和两亲性。这些因素中的每一个都可能有助于 ACP 的抗癌作用，但没有一个单一的因素（s）对它们的整体选择性和毒性有压倒性的贡献。ACPs 抗癌作用的差异似乎与这些肽和基于膜的因素之间不同程度的相互作用有关。
