Peuckert W
Universitäts-Kinderklinik Freiburg.
Monatsschr Kinderheilkd. 1990 Apr;138(4):190-5.
Lyme borreliosis is a tick-borne mediated systemic inflammatory disorder caused by a newly recognized spirochete, Borrelia burgdorferi. Its clinical hallmark is an early expanding skin lesion, erythema chronicum migrans (ECM) which may be followed weeks to months later by neurological, cardiac, or joint abnormalities. Symptoms may be associated with any of these systems alone or in combination. All stages of Lyme borreliosis may respond to antibiotics, but treatment of early disease is the most successful. Foci of Lyme borreliosis are widely distributed within the USA and Europe and the disorder appears to be worldwide. Although there are some variations in clinical expression between the USA and Europe, the various syndromes, Erythema migrans (Afzelius), Meningopolyneuritis [Garin-Bujadoux, Bannwarth (MPN)] are now generally subsumed under the name Lyme borreliosis. B. burdorferi is also responsible for an early skin lesion, Borrelia lymphozytom [Lymphadenosis cutis benigna (LCB)], and for a late one, Acrodermatitis chronica atrophicans (ACA), both seen primarily in Europe. In the USA joint abnormalities are the leading abnormalities in the later manifestation of the disease. Lyme borreliosis grew up in the last ten years as a new nosologic entity with some aspects for an infectious etiology of rheumatic disease.
莱姆病是一种由新发现的螺旋体——伯氏疏螺旋体引起的蜱传播介导的全身性炎症性疾病。其临床特征是早期出现不断扩大的皮肤病变，即慢性游走性红斑（ECM），数周或数月后可能继以神经、心脏或关节异常。症状可能单独或合并出现于这些系统中的任何一个。莱姆病的各个阶段对抗生素治疗均可能有反应，但早期疾病的治疗最为成功。莱姆病的病灶在美国和欧洲广泛分布，且该疾病似乎在全球范围内都有。尽管美国和欧洲在临床表现上存在一些差异，但各种综合征，如游走性红斑（阿费利乌斯）、脑膜多神经炎[加兰 - 布雅杜综合征，班沃思综合征（MPN）]现在通常都归入莱姆病这一名称之下。伯氏疏螺旋体还会引起一种早期皮肤病变，即淋巴细胞瘤性伯氏疏螺旋体病[皮肤良性淋巴腺病（LCB）]，以及一种晚期病变，即慢性萎缩性肢端皮炎（ACA），这两种病变主要见于欧洲。在美国，关节异常是该疾病后期表现中的主要异常情况。莱姆病在过去十年中作为一种新的病种出现，在某些方面提示了风湿性疾病的感染病因。
