Mukund A, Gamanagatti S, Acharya S K
Department of Radiology, All India Institute of Medical Sciences, New Delhi, India - 110029.
Trop Gastroenterol. 2011 Jan-Mar;32(1):4-14.
Hepatic venous outflow tract obstruction (HVOTO) comprises of constellation of disorders causing obstruction of hepatic venous outflow or suprahepatic inferior vena cava (IVC) or both and leading to increased hepatic sinusoidal pressure and portal hypertension. Clinical presentation in HVOTO includes both acute onset or chronic insidious onset of the disease and predominant clinical manifestations consist of ascites, hepatomegaly, and portal hypertension. IVC/hepatic vein (HV) web or thrombosed hepatic veins replaced by fibrotic constriction or thrombus in suprahepatic IVC is encountered as the pathogenic process at such obstructions. Due to advances in radiologic techniques there has been a changes in the management protocol of HVOTO with surgery or liver transplantation reserved for patients not suitable for radiological interventions or requiring liver transplantation. The present article reviews the techniques of various radiological interventions in HVOTO and their efficacy.
肝静脉流出道梗阻(HVOTO)是一组导致肝静脉流出道或肝上下腔静脉(IVC)或两者均受阻的疾病,进而导致肝窦压力升高和门静脉高压。HVOTO的临床表现包括疾病的急性发作或慢性隐匿性发作,主要临床表现为腹水、肝肿大和门静脉高压。IVC/肝静脉(HV)网或被肝上下腔静脉的纤维化狭窄或血栓替代的血栓形成的肝静脉是此类梗阻的致病过程。由于放射学技术的进步,HVOTO的管理方案发生了变化,手术或肝移植仅适用于不适合放射学干预或需要肝移植的患者。本文综述了HVOTO中各种放射学干预技术及其疗效。