Tyrer P, Seivewright N, Ferguson B, Murphy S, Darling C, Brothwell J, Kingdon D, Johnson A L
Mapperley Hospital, Nottingham.
Psychol Med. 1990 May;20(2):423-31. doi: 10.1017/s0033291700017736.
Two hundred and ten psychiatric patients with one of three DSM-III diagnoses, generalized anxiety disorder (N = 71), panic disorder (N = 74) or dysthymic disorder (N = 65), were included in a clinical trial in which diazepam, dothiepin or placebo tablets, cognitive and behaviour therapy, or a self-help package were given over ten weeks. Personality status was assessed independently using a structured interview, the Personality Assessment Schedule. One hundred and ninety-eight patients had personality assessments, 89% with a close informant. Thirty-six per cent had a personality disorder and these patients had more severe psychopathology than those with no personality disorder. Personality disorder was more common in patients with dysthymic disorder and this group responded less well to treatment. The category of personality disorder had no apparent influence on symptoms.
210名患有以下三种DSM-III诊断之一的精神科患者被纳入一项临床试验：广泛性焦虑症（N = 71）、惊恐障碍（N = 74）或心境恶劣障碍（N = 65）。在该试验中，患者在十周内服用地西泮、多塞平或安慰剂片剂，并接受认知行为疗法或自助方案。使用结构化访谈工具“人格评估量表”独立评估人格状态。198名患者接受了人格评估，其中89%的评估有亲密知情者参与。36%的患者有人格障碍，这些患者的精神病理学症状比没有人格障碍的患者更严重。人格障碍在心境恶劣障碍患者中更为常见，且该组患者对治疗的反应较差。人格障碍类别对症状没有明显影响。
